Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV)

• Published in: Virus research Vol. 349; p. 199458
• Main Authors: Sitinjak, Mikael Cristofer, Chen, Jui-Kai, Liu, Fang-Lin, Hou, Ming-Hon, Lin, Shan-Meng, Liu, Hung-Jen, Wang, Chi-Young
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2024; Elsevier
• Subjects: Amino Acid Sequence; Animals; Antiviral Agents - pharmacology; Antivirals; Cell Line; Cell Membrane Permeability; Chick Embryo; Chickens; Computational Biology; Coronavirus; Coronavirus Infections - drug therapy; Escherichia coli; Infectious bronchitis virus - chemistry; Infectious bronchitis virus - drug effects; Infectious bronchitis virus - isolation & purification; Infectious bronchitis virus - metabolism; Molecular Docking Simulation; Protein Multimerization; Serogroup; Viroporin; Viroporin Proteins - antagonists & inhibitors; Viroporin Proteins - chemistry; Viroporin Proteins - genetics; Viroporin Proteins - metabolism; Coronavirus; Antivirals; Viroporin

•The envelope (E) proteins of infectious bronchitis virus (IBV) resulted in inhibited bacteria growth, increased permeability of bacteria, and blocked protein synthesis of bacteria.•Hygromycin B impeded protein translation in DF-1 cells and damaged their membrane integrity in the presence of E prote...