Platelet Activation and Apoptosis Modulate Monocyte Inflammatory Responses in Dengue

• Published in: The Journal of immunology (1950) Vol. 193; no. 4; pp. 1864 - 1872
• Main Authors: Hottz, Eugenio D, Medeiros-de-Moraes, Isabel M, Vieira-de-Abreu, Adriana, de Assis, Edson F, Vals-de-Souza, Rogério, Castro-Faria-Neto, Hugo C, Weyrich, Andrew S, Zimmerman, Guy A, Bozza, Fernando A, Bozza, Patrícia T
• Format: Journal Article
• Language: English
• Published: United States 15.08.2014
• Subjects: Adult; Apoptosis - immunology; Arbovirus; Blood Platelets - immunology; Capillary Permeability; Chemokine CCL2 - metabolism; Dengue - immunology; Dengue Virus - immunology; Female; Humans; Inflammation - immunology; Interleukin-10 - metabolism; Interleukin-1beta - metabolism; Interleukin-8 - metabolism; Male; Monocytes - immunology; P-Selectin - immunology; Phagocytosis; Phosphatidylserines - immunology; Platelet Activation - immunology; Thrombocytopenia - immunology

Dengue is the most prevalent human arbovirus disease in the world. Dengue infection has a large spectrum of clinical manifestations, from self-limited febrile illness to severe syndromes accompanied by bleeding and shock. Thrombocytopenia and vascular leak with altered cytokine profiles in plasma ar...