Seasonal hepatic cytochrome P-450 induction in cotton rats ( Sigmodon hispidus) inhabiting petrochemical waste sites

• Published in: Environmental pollution (1987) Vol. 105; no. 2; pp. 191 - 196
• Main Authors: Lochmiller, R.L, McMurry, S.T, McBee, K, Rafferty, D.P, Lish, J.W, Qualls, C.W
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.01.1999; Elsevier
• Subjects: Animal, plant and microbial ecology; Applied ecology; Biological and medical sciences; Cytochrome P-450; Ecotoxicology, biological effects of pollution; Effects of pollution and side effects of pesticides on vertebrates; Fundamental and applied biological sciences. Psychology; Mammalia; Petrochemical contaminants; Sigmodon hispidus; Wildlife toxicology; United States; North America; Oklahoma; America; Petrochemical contaminants; Sigmodon hispidus; Cytochrome P-450; Wildlife toxicology; Induction; Isozyme; Toxicity; Cytochrome P450; Liver; Rodentia; Wild animal; Contamination; Petrochemical industry; Vertebrata; Mammalia; Enzymatic activity; Seasonal variation; Wastes; Biological effect

Wildlife species inhabiting contaminated sites are often exposed to complex mixtures of chemicals that have known effects on physiological and biochemical function. We evaluated the induction of major hepatic cytochrome P-450 isoenzymes through O-dealkylation of various resorufin ethers in wild cott...