Noninvasive Relative Quantification of [11C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt

• Published in: Frontiers in neurology Vol. 9; p. 516
• Main Authors: Verhaeghe, Jeroen, Bertoglio, Daniele, Kosten, Lauren, Thomae, David, Verhoye, Marleen, Van Der Linden, Annemie, Wyffels, Leonie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.06.2018
• Subjects: [11C]ABP688; input function; mGluR5; Neurology; PET imaging; test-retest; input function; [11C]ABP688; PET imaging; mGluR5; test-retest

Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified with the PET radiotracer [ C]ABP688, the methods for reproducible quantification of [ C]ABP688 PET imaging in mice have not been thoroughly in...