Enhancement of antibacterial activity in electrospun fibrous membranes based on quaternized chitosan with caffeic acid and berberine chloride for wound dressing applications

• Published in: RSC advances Vol. 14; no. 47; pp. 34756 - 34768
• Main Authors: Chiu, Po-Hsun, Wu, Zhao-Yi, Hsu, Chih-Chin, Chang, Yung-Chi, Huang, Chang-Ming, Hu, Cheng-Ti, Lin, Che-Min, Chang, Shin C, Hsieh, Hsyue-Jen, Dai, Chi-An
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 29.10.2024; The Royal Society of Chemistry
• Subjects: Acids; Antiinfectives and antibacterials; Biocompatibility; Chemistry; Chitosan; Chlorides; E coli; Electrospinning; Mechanical properties; Membranes; Nanofibers; Solubility; Surgical dressings; Surgical equipment; Survival; Tensile strength; Water stability; Wound healing

Electrospun nanofibers made from chitosan are promising materials for surgical wound dressings due to their non-toxicity and biocompatibility. However, the antibacterial activity of chitosan is limited by its poor water solubility under physiological conditions. This study addresses this issue by pr...