FXR, MRP-1 and SLC7A5: New Targets for the Treatment of Hepatocellular Carcinoma

• Published in: Technology in cancer research & treatment Vol. 23; p. 15330338241276889
• Main Authors: Zhang, Xi-yue, Luo, Ming, Qin, Shu, Fu, Wen-guang, Zhang, Meng-yu
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2024; Sage Publications Ltd; SAGE Publishing
• Subjects: Amino Acid Transport System y+ - genetics; Amino Acid Transport System y+ - metabolism; Animal models; Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Diethylnitrosamine; Disease Models, Animal; Drug delivery; Drug development; Drug resistance; Gene therapy; Glyceraldehyde-3-phosphate dehydrogenase; Hepatocellular carcinoma; Hepatocytes; Liver; Liver - metabolism; Liver - pathology; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; mRNA; MRP1 protein; Multidrug resistance; Multidrug Resistance-Associated Proteins - genetics; Multidrug Resistance-Associated Proteins - metabolism; Proteins; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Therapeutic targets; Tumors; FXR; SLC7A5; HCC; MRP-1; DEN

Detect the expression of Farnesoid X Receptor(FXR), Multiple Drug Resistance Associated Protein-1(MRP-1) and Solute Carrier Family 7, Member 5 (SLC7A5) in hepatocellular carcinoma(HCC) of rat model, so as to provide new therapeutic targets for gene therapy of HCC. Sixty male Wistar rats were randoml...