The ABC gene family in arthropods: Comparative genomics and role in insecticide transport and resistance

• Published in: Insect biochemistry and molecular biology Vol. 45; pp. 89 - 110
• Main Authors: Dermauw, Wannes, Van Leeuwen, Thomas
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2014
• Subjects: ABC transporters; adenosine triphosphate; Allelochemicals; Animals; Arthropoda; arthropods; Arthropods - genetics; Arthropods - metabolism; ATP-Binding Cassette Transporters - chemistry; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - physiology; Bacillus thuringiensis; BCRP; Bt toxins; Crustacea; Detoxification; Drosophila; Drosophila - genetics; drug resistance; gene expression regulation; genes; Genomics; humans; Insecticide Resistance; insecticides; insects; Lepidoptera; lipids; MDR; mechanism of action; Models, Molecular; MRP; Multidrug resistance; mutants; P-gp; Phase III; Phylogeny; Primary carriers; SUR; toxicology; toxins; Traffic ATPases; transgenic plants; xenobiotics; BCRP; P-gp; Bt toxins; Multidrug resistance; Detoxification; MRP; Allelochemicals; Primary carriers; Phase III; SUR; Traffic ATPases; Arthropoda; MDR

About a 100 years ago, the Drosophila white mutant marked the birth of Drosophila genetics. The white gene turned out to encode the first well studied ABC transporter in arthropods. The ABC gene family is now recognized as one of the largest transporter families in all kingdoms of life. The majority...