IPA-3: An Inhibitor of Diadenylate Cyclase of Streptococcus suis with Potent Antimicrobial Activity

• Published in: Antibiotics (Basel) Vol. 11; no. 3; p. 418
• Main Authors: Li, Haotian, Li, Tingting, Zou, Wenjin, Ni, Minghui, Hu, Qiao, Qiu, Xiuxiu, Yao, Zhiming, Fan, Jingyan, Li, Lu, Huang, Qi, Zhou, Rui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.03.2022; MDPI
• Subjects: Antibiotics; antimicrobial; Antimicrobial activity; Antimicrobial agents; Antimicrobial resistance; Bacteria; Binding sites; Biofilms; Chromatography; cyclic diadenylate monophosphate; diadenylate cyclase; Drug resistance; E coli; Enzymatic activity; Gram-positive bacteria; Health risks; High performance liquid chromatography; high-throughput screening; Homeostasis; inhibitor; Inhibitors; IPA-3; Kinases; Liquid chromatography; Meningitis; Molecular docking; Physiology; Proteins; Public health; Screening; Streptococcus infections; Streptococcus suis; Therapeutic targets; Virulence; antimicrobial; diadenylate cyclase; inhibitor; Streptococcus suis; high-throughput screening; IPA-3; cyclic diadenylate monophosphate

Antimicrobial resistance (AMR) poses a huge threat to public health. The development of novel antibiotics is an effective strategy to tackle AMR. Cyclic diadenylate monophosphate (c-di-AMP) has recently been identified as an essential signal molecule for some important bacterial pathogens involved i...