Biologic treatment of pediatric rheumatic diseases: are we spoilt for choice?

Approximately 15 years ago the first biological treatment for juvenile idiopathic arthritis (JIA) was introduced. Since the introduction of the TNF receptor fusion protein etanercept in 1998, now more than seven biologics are now registered, or under study for JIA. [...]when pharmaceuticals submit a...

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Published inImmunotherapy Vol. 6; no. 1; pp. 1 - 3
Main Authors van Royen-Kerkhof, Annet, Vastert, Bas SJ, Swart, Joost F, Wulffraat, Nico M
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.01.2014
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Abstract Approximately 15 years ago the first biological treatment for juvenile idiopathic arthritis (JIA) was introduced. Since the introduction of the TNF receptor fusion protein etanercept in 1998, now more than seven biologics are now registered, or under study for JIA. [...]when pharmaceuticals submit a registration proposal to EMA, a Pediatric Investigational Plan must be included. Furthermore, treatment with biosimilars should be closely monitored for quality and safety. [...]introduction of biosimilars will only lead to a limited cost reduction.
AbstractList Approximately 15 years ago the first biological treatment for juvenile idiopathic arthritis (JIA) was introduced. Since the introduction of the TNF receptor fusion protein etanercept in 1998, now more than seven biologics are now registered, or under study for JIA. [...]when pharmaceuticals submit a registration proposal to EMA, a Pediatric Investigational Plan must be included. Furthermore, treatment with biosimilars should be closely monitored for quality and safety. [...]introduction of biosimilars will only lead to a limited cost reduction.
Audience Academic
Author Vastert, Bas SJ
Wulffraat, Nico M
van Royen-Kerkhof, Annet
Swart, Joost F
AuthorAffiliation Department of Pediatric Immunology & Rheumatology, Wilhelmina Children s Hospital University Medical Center, Utrecht, The Netherlands
Department of Pediatric Immunology & Rheumatology, Wilhelmina Children s Hospital University Medical Center, Utrecht, The Netherlands. n.wulffraat@umcutrecht.nl
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Snippet Approximately 15 years ago the first biological treatment for juvenile idiopathic arthritis (JIA) was introduced. Since the introduction of the TNF receptor...
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SubjectTerms Adolescent
Anti-Inflammatory Agents - economics
Anti-Inflammatory Agents - therapeutic use
Antibodies, Monoclonal - economics
Antibodies, Monoclonal - therapeutic use
Arthritis
Biological products
Biological Therapy - methods
Biological Therapy - trends
biologicals
Care and treatment
Child
Children
Clinical medicine
Cost-Benefit Analysis
Costs
Disease
Diseases
Etanercept
Europe
Humans
Immunoglobulin G - economics
Immunoglobulin G - therapeutic use
Immunotherapy
Interleukin 1 Receptor Antagonist Protein - economics
Interleukin 1 Receptor Antagonist Protein - therapeutic use
Interleukin-1 - antagonists & inhibitors
juvenile idiopathic arthritis
Medical research
Pediatrics
Pharmaceutical industry
Proteins
Receptors, Tumor Necrosis Factor - therapeutic use
Rheumatic diseases
Rheumatic Diseases - economics
Rheumatic Diseases - immunology
Rheumatic Diseases - therapy
safety aspect
Studies
Tumor Necrosis Factor-alpha - antagonists & inhibitors
United States
Title Biologic treatment of pediatric rheumatic diseases: are we spoilt for choice?
URI http://dx.doi.org/10.2217/imt.13.153
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