Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). Evidence for intermittent somatostatin secretion

• Published in: The Journal of clinical investigation Vol. 75; no. 5; pp. 1584 - 1590
• Main Authors: Vance, M L, Kaiser, D L, Evans, W S, Furlanetto, R, Vale, W, Rivier, J, Thorner, M O
• Format: Journal Article
• Language: English
• Published: Ann Arbor, MI American Society for Clinical Investigation 01.05.1985
• Subjects: Acromegaly - metabolism; Adult; Biological and medical sciences; Drug Interactions; Fundamental and applied biological sciences. Psychology; Growth Hormone - secretion; Growth Hormone-Releasing Hormone - administration & dosage; Hormones and neuropeptides. Regulation; Humans; Hypothalamus. Hypophysis. Epiphysis. Urophysis; Infusions, Parenteral; Insulin-Like Growth Factor I; Male; Middle Aged; Peptide Fragments - administration & dosage; Somatomedins - blood; Somatostatin - secretion; Time Factors; Vertebrates: endocrinology; Human; Protein hormone; Secretion curve; STH; Peptide hormone; Hormonal regulation; Somatostatin; Neuropeptide; Biological activity; STH-RH

Growth hormone (GH) secretory patterns were studied in a patient with ectopic growth hormone releasing factor (GRF) secretion and in normal men given continuous infusions of human growth hormone releasing factor (1-40)-OH (hGRF-40). In the patient with ectopic GRF secretion, GH secretion was pulsati...