Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data

• Published in: British journal of cancer Vol. 73; no. 4; pp. 447 - 456
• Main Authors: BAXTER, L. T, JAIN, R. K
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.02.1996
• Subjects: Antibodies - immunology; Antibodies - metabolism; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - metabolism; Antineoplastic agents; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Biotransformation; Enzymes - pharmacokinetics; General aspects; Humans; Medical sciences; Models, Biological; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - metabolism; Pharmacology. Drug treatments; Prodrugs - pharmacokinetics; Sensitivity and Specificity; Tissue Distribution; Antineoplastic agent; Human; Drug; Enzyme; Antibody directed enzyme prodrug therapy; Monoclonal antibody; Prodrug; Malignant tumor; Treatment; Distribution; Simulation model; Mathematical model; Pharmacokinetics

A mathematical model was developed to improve understanding of the biodistribution and microscopic profiles of drugs and prodrugs in a system using enzyme-conjugated antibodies as part of a two-step method for cancer treatment. The use of monoclonal antibodies alone may lead to heterogeneous uptake...