A diametric role for OX40 in the response of effector/memory CD4+ T cells and regulatory T cells to alloantigen

• Published in: The Journal of immunology (1950) Vol. 191; no. 3; pp. 1465 - 1475
• Main Authors: Kinnear, Gillian, Wood, Kathryn J, Fallah-Arani, Farnaz, Jones, Nick D
• Format: Journal Article
• Language: English
• Published: United States 01.08.2013
• Subjects: Adaptive Immunity - immunology; Animals; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Cell Movement; Cell Proliferation; Homeodomain Proteins - genetics; Immune Tolerance; Immunologic Memory; Isoantigens - immunology; Lymphocyte Activation - immunology; Membrane Glycoproteins - immunology; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; OX40 Ligand; Receptors, OX40 - immunology; Receptors, OX40 - metabolism; Signal Transduction - immunology; Skin Transplantation - immunology; T-Lymphocytes, Regulatory - immunology; Transplantation, Homologous - immunology; Tumor Necrosis Factors - immunology; Tumor Necrosis Factors - metabolism

OX40 is a member of the TNFR superfamily that has potent costimulatory properties. Although the impact of blockade of the OX40-OX40 ligand (OX40L) pathway has been well documented in models of autoimmune disease, its effect on the rejection of allografts is less well defined. In this article, we sho...