Advances in screening instruments for Alzheimer's disease
At its fundamental basis, Alzheimer's disease (AD) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic memory. This review will provide a rationale for calls to screen for the early detection of AD, appraise the currently available cognitive inst...
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| Published in | Aging medicine Vol. 2; no. 2; pp. 88 - 93 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Australia
John Wiley & Sons, Inc
01.06.2019
John Wiley and Sons Inc Wiley |
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| Online Access | Get full text |
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| Abstract | At its fundamental basis, Alzheimer's disease (AD) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic memory. This review will provide a rationale for calls to screen for the early detection of AD, appraise the currently available cognitive instruments for AD detection, and focus on the development of the MemTrax test, which provides a new approach to detect the early manifestations and progression of the dementia associated with AD. MemTrax assesses metrics that reflect the effects of neuroplastic processes on learning, memory, and cognition, which are affected by age and AD, particularly episodic memory functions, which cannot presently be measured with enough precision for meaningful use. Further development of MemTrax would be of great value to the early detection of AD and would provide support for the testing of early interventions. |
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| AbstractList | At its fundamental basis, Alzheimer's disease (AD) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic memory. This review will provide a rationale for calls to screen for the early detection of AD, appraise the currently available cognitive instruments for AD detection, and focus on the development of the MemTrax test, which provides a new approach to detect the early manifestations and progression of the dementia associated with AD. MemTrax assesses metrics that reflect the effects of neuroplastic processes on learning, memory, and cognition, which are affected by age and AD, particularly episodic memory functions, which cannot presently be measured with enough precision for meaningful use. Further development of MemTrax would be of great value to the early detection of AD and would provide support for the testing of early interventions. At its fundamental basis, Alzheimer's disease ( AD ) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic memory. This review will provide a rationale for calls to screen for the early detection of AD , appraise the currently available cognitive instruments for AD detection, and focus on the development of the MemTrax test, which provides a new approach to detect the early manifestations and progression of the dementia associated with AD . MemTrax assesses metrics that reflect the effects of neuroplastic processes on learning, memory, and cognition, which are affected by age and AD , particularly episodic memory functions, which cannot presently be measured with enough precision for meaningful use. Further development of MemTrax would be of great value to the early detection of AD and would provide support for the testing of early interventions. Abstract At its fundamental basis, Alzheimer's disease ( AD ) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic memory. This review will provide a rationale for calls to screen for the early detection of AD , appraise the currently available cognitive instruments for AD detection, and focus on the development of the MemTrax test, which provides a new approach to detect the early manifestations and progression of the dementia associated with AD . MemTrax assesses metrics that reflect the effects of neuroplastic processes on learning, memory, and cognition, which are affected by age and AD , particularly episodic memory functions, which cannot presently be measured with enough precision for meaningful use. Further development of MemTrax would be of great value to the early detection of AD and would provide support for the testing of early interventions. Abstract At its fundamental basis, Alzheimer's disease (AD) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic memory. This review will provide a rationale for calls to screen for the early detection of AD, appraise the currently available cognitive instruments for AD detection, and focus on the development of the MemTrax test, which provides a new approach to detect the early manifestations and progression of the dementia associated with AD. MemTrax assesses metrics that reflect the effects of neuroplastic processes on learning, memory, and cognition, which are affected by age and AD, particularly episodic memory functions, which cannot presently be measured with enough precision for meaningful use. Further development of MemTrax would be of great value to the early detection of AD and would provide support for the testing of early interventions. |
| Author | Ashford, J. Wesson Zhou, Xianbo |
| AuthorAffiliation | 1 SJN Biomed LTD Kunming China 4 Department of Psychiatry and Behavioral Sciences Stanford University Stanford California USA 3 War Related Illness and Injury Study Center VA Palo Alto Health Care System Palo Alto California USA 2 Center for Alzheimer's Research Washington Institute of Clinical Research Washington District of Columbia USA |
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| Cites_doi | 10.1212/01.WNL.0000055813.36504.BF 10.1186/s13195-019-0474-3 10.1212/01.WNL.0000163773.21794.0B 10.1002/gps.738 10.1016/j.jalz.2018.02.018 10.1186/1471-2377-12-119 10.3233/JAD-2003-5506 10.1212/WNL.0000000000007021 10.1016/S0022-5371(67)80067-7 10.3233/JAD-161208 10.1016/0306-4522(95)90397-P 10.3233/jad-190167 10.3233/JAD-181198 10.1016/S1474-4422(12)70291-0 10.1080/13607863.2011.596805 10.3233/JAD-181003 10.1016/j.actpsy.2018.01.012 10.1016/j.jalz.2018.12.011 10.18632/aging.100690 10.1126/science.273.5271.28 10.1126/science.9304205 10.1111/jgs.13234 10.1186/s13195-017-0297-z 10.1016/j.jalz.2012.08.008 10.1001/jamaneurol.2017.1658 10.3233/JAD-181009 10.1016/S0197-4580(97)00063-8 10.2217/1745509X.4.4.399 10.1080/14640747308400340 10.1016/j.jalz.2017.12.006 10.3233/JAD-2008-15109 |
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| Copyright | 2019 The Authors. published by Beijing Hospital and John Wiley & Sons Australia, Ltd. 2019 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd. 2019. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Snippet | At its fundamental basis, Alzheimer's disease (AD) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic memory.... Abstract At its fundamental basis, Alzheimer's disease ( AD ) is a pathological process that affects neuroplasticity, leading to a specific disruption of... At its fundamental basis, Alzheimer's disease ( AD ) is a pathological process that affects neuroplasticity, leading to a specific disruption of episodic... Abstract At its fundamental basis, Alzheimer's disease (AD) is a pathological process that affects neuroplasticity, leading to a specific disruption of... |
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| SubjectTerms | Alzheimer's disease Biomarkers Cognition & reasoning Cognitive ability Dementia Disease prevention Hypertension Medical imaging Memory Neurodegeneration Review screen screening instrument Special Issue: Dementia Task forces |
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| Title | Advances in screening instruments for Alzheimer's disease |
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