The role of HOX genes in head and neck squamous cell carcinoma

• Published in: Journal of oral pathology & medicine Vol. 45; no. 4; pp. 239 - 247
• Main Authors: Platais, Christopher, Hakami, Fahad, Darda, Lav, Lambert, Daniel W., Morgan, Richard, Hunter, Keith D.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.04.2016
• Subjects: Animals; Biomarkers, Tumor - genetics; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell Differentiation - physiology; Gene Expression Regulation, Neoplastic; Genes, Homeobox; head and neck cancer; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; head and neck squamous cell carcinoma; Homeobox; HOX genes; Humans; Multigene Family; Squamous Cell Carcinoma of Head and Neck; Homeobox; HOX genes; head and neck cancer; head and neck squamous cell carcinoma

Recent decades have witnessed the publication of numerous studies reporting alterations in the genome and transcriptome of head and neck squamous cell carcinoma (HNSCC). Currently, the utilisation of these alterations as biomarkers and targets for therapy is limited and new, useful molecular charact...