Controlled trial of ligation plus vasoconstrictor versus proton pump inhibitor in the control of acute esophageal variceal bleeding

• Published in: Journal of gastroenterology and hepatology Vol. 28; no. 4; pp. 684 - 689
• Main Authors: Lo, Gin-Ho, Perng, Daw-Shyong, Chang, Chi-Yang, Tai, Chi-Ming, Wang, Huay-Min, Lin, Hui-Chen
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.04.2013
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles - adverse effects; 2-Pyridinylmethylsulfinylbenzimidazoles - therapeutic use; Adult; Aged; banding ligation; Combined Modality Therapy; Esophageal and Gastric Varices - mortality; Esophageal and Gastric Varices - therapy; Esophagoscopy; Female; Gastrointestinal Hemorrhage - mortality; Gastrointestinal Hemorrhage - therapy; Hemostasis; Humans; Ligation; Lypressin - adverse effects; Lypressin - analogs & derivatives; Lypressin - therapeutic use; Male; Middle Aged; Omeprazole - adverse effects; Omeprazole - therapeutic use; proton pump inhibitor; Proton Pump Inhibitors - adverse effects; Proton Pump Inhibitors - therapeutic use; Recurrence; Somatostatin - adverse effects; Somatostatin - therapeutic use; Treatment Outcome; vasoconstrictor; Vasoconstrictor Agents - adverse effects; Vasoconstrictor Agents - therapeutic use

Background Endoscopic therapy combined with vasoconstrictor was generally recommended to treat acute variceal bleeding. However, up to 30% of patients may still encounter treatment failure. Objectives This trial was to evaluate the efficacy of combination with endoscopic variceal ligation (EVL) and...