Entamoeba histolytica: electron-dense granule secretion, collagenase activity and virulence are altered in the cytoskeleton mutant BG-3

HM-1:IMSS, a pathogenic strain of Entamoeba histolytica, and its mutant BG-3, identified by resistance to cytochalasin D, were tested for their capacity to: (i) secrete electron-dense granules; (ii) adhere and digest native type I collagen gels; and (iii) produce liver abscesses in new-born hamsters...

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Published inMolecular microbiology Vol. 11; no. 4; p. 787
Main Authors Serrano, J J, de la Garza, M, Moreno, M A, Tovar, R, León, G, Tsutsumi, V, Muñoz, M L
Format Journal Article
LanguageEnglish
Published England 01.02.1994
Subjects
Animals
Animals, Newborn
Cell Adhesion
Collagen
Collagenases - analysis
Cricetinae
Cytochalasin D - pharmacology
Cytoplasmic Granules - metabolism
Cytoskeleton - ultrastructure
Drug Resistance - genetics
Entamoeba histolytica - drug effects
Entamoeba histolytica - enzymology
Entamoeba histolytica - genetics
Entamoeba histolytica - pathogenicity
Entamoeba histolytica - ultrastructure
Liver Abscess, Amebic - parasitology
Mesocricetus
Mutation
Protozoan Proteins - analysis
Virulence - genetics
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Summary:HM-1:IMSS, a pathogenic strain of Entamoeba histolytica, and its mutant BG-3, identified by resistance to cytochalasin D, were tested for their capacity to: (i) secrete electron-dense granules; (ii) adhere and digest native type I collagen gels; and (iii) produce liver abscesses in new-born hamsters. The results demonstrate that the mutant has low adherence to collagen, low electron-dense granule secretion and collagenolytic activity, and low capacity to produce liver lesions in vivo, compared with the parental strain HM1:IMSS.
ISSN:0950-382X
DOI:10.1111/j.1365-2958.1994.tb00356.x