Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis

• Published in: Oncogene Vol. 22; no. 36; pp. 5579 - 5585
• Main Authors: HAGA, Naomi, FUJITA, Naoya, TSURUO, Takashi
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 28.08.2003; Nature Publishing Group
• Subjects: Ageing, cell death; Animals; Apoptosis; Apoptosis - drug effects; Bcl-x protein; Biological and medical sciences; Caspase 3; Caspases - physiology; Cell death; Cell Line; Cell physiology; COS Cells; Cytochrome; Cytochrome c; Cytochrome c Group - secretion; Cytometry; Cytoplasm; Etoposide - pharmacology; Fundamental and applied biological sciences. Psychology; Humans; Localization; Mitochondria; Mitochondria - physiology; Molecular and cellular biology; Morphology; Signal transduction; Transfection; Japan; Aggregation; Cytochrome c; Mitochondria; laser scanning cytometer; Release; Apoptosis

Mitochondria play a central role in apoptotic signaling pathways. Upon exposure to apoptotic stimuli, mitochondria release cytochrome c to the cytoplasm and activate caspase cascade leading to cell death. However, the events upstream of cytochrome c release are not fully understood. Here, we quantit...