Bone-Grafting in Polyostotic Fibrous Dysplasia

• Published in: Journal of bone and joint surgery. American volume Vol. 98; no. 3; p. 211
• Main Authors: Leet, Arabella I, Boyce, Alison M, Ibrahim, Khalda A, Wientroub, Shlomo, Kushner, Harvey, Collins, Michael T
• Format: Journal Article
• Language: English
• Published: United States 03.02.2016
• Subjects: Adolescent; Adult; Allografts; Autografts; Bone Transplantation; Child; Child, Preschool; Facial Bones; Female; Fibrous Dysplasia, Polyostotic - surgery; Graft Survival; Humans; Kaplan-Meier Estimate; Male; Prognosis; Proportional Hazards Models; Retrospective Studies; Skull; Young Adult

Polyostotic fibrous dysplasia is a skeletal disease that results from somatic activating mutations in the gene GNAS in skeletal stem cells, leading to proliferation of immature osteogenic cells with replacement of normal marrow and bone with fibro-osseous tissue. Lesions may cause bone deformity or...