Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study

• Published in: The Prostate Vol. 59; no. 4; pp. 357 - 359
• Main Authors: Lubieniecka, Joanna M., Cheteri, Mahesh Keitheri, Stanford, Janet L., Ostrander, Elaine A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2004
• Subjects: Adult; Case-Control Studies; gene; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; mutation; Pedigree; Polymorphism, Genetic; Prostatic Neoplasms - genetics; Risk Factors; Serine Endopeptidases - genetics; serine protease; urologic cancer

BACKGROUND Serine proteases play an important role in prostate cancer (PCa) invasion through the degradation of extracellular matrix proteins and interaction with growth modulating factors. The transmembrane serine protease 2 (TMPRSS2) gene encodes a type II transmembrane protein which, due to its c...