Short-term venom immunotherapy induces desensitization of FcεRI-mediated basophil response

• Published in: Allergy (Copenhagen) Vol. 67; no. 12; pp. 1594 - 1600
• Main Authors: Čelesnik, N., Vesel, T., Rijavec, M., Šilar, M., Eržen, R., Košnik, M., Kloft Žitnik, S. E., Avčin, T., Korošec, P.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.12.2012
• Subjects: Adolescent; Adult; Aged; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - immunology; basophils; Basophils - drug effects; Basophils - immunology; Basophils - metabolism; Child; Child, Preschool; Children; Desensitization, Immunologic; Fc receptors; Female; Gene Expression Profiling; high-affinity IgE receptor/FcεRI; Humans; Hymenoptera allergy; Hypersensitivity - genetics; Hypersensitivity - immunology; Hypersensitivity - therapy; Immunoglobulin E; Immunotherapy; Insect Bites and Stings; Leukocyte Count; Leukocytes (basophilic); Male; Middle Aged; Receptor mechanisms; Receptors, IgE - genetics; Receptors, IgE - immunology; Receptors, IgE - metabolism; short-term venom immunotherapy; Venom; Venoms - administration & dosage; Venoms - immunology; Young Adult

Background The precise immunological mechanisms for the early clinical protection of venom immunotherapy (VIT) have not yet been explained. Our aim was to evaluate whether high‐affinity IgE receptor (FcεRI) and the related basophil function have a role in the induction of short‐term VIT protection....