In vivo biostability of polysiloxane polyether polyurethanes: Resistance to metal ion oxidation

• Published in: Journal of biomedical materials research. Part A Vol. 77A; no. 2; pp. 380 - 389
• Main Authors: Ward, Bob, Anderson, James, Ebert, Mike, McVenes, Rick, Stokes, Ken
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2006
• Subjects: Animals; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; biostability; Cobalt - chemistry; Hydrogen Peroxide - chemistry; In Vitro Techniques; Ions - chemistry; Materials Testing; MIO; Molecular Weight; Oxidants - chemistry; Oxidation-Reduction; polyurethane; Polyurethanes - chemistry; Polyurethanes - metabolism; Prostheses and Implants; Rabbits; silicone modified polyurethane; Siloxanes - chemistry; Siloxanes - metabolism; Surface Properties; Tensile Strength

Polyether polyurethanes are subject to oxidation catalyzed by and through direct (redox) reaction with transition metal ions (cobalt), released by corrosion of metallic parts in an implanted device. Replacing part of the polyether with polysiloxane appears to reduce susceptibility to metal ion oxida...