Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1

• Published in: Wellcome open research Vol. 2; p. 87
• Main Authors: Billman, Martin R, Rueda, David, Bangham, Charles R M
• Format: Journal Article
• Language: English
• Published: England Wellcome Trust Limited 2017; F1000 Research Limited; Wellcome
• Subjects: Binding sites; Cell culture; Cell cycle; Cell growth; Cell Signaling; Cloning; Control of Gene Expression; Gene expression; Genomes; Infectious diseases; Leukemia; Lymphocytes; Medical Genetics; Patients; Virology; Writing; United Kingdom > UK; retrovirus; transcription; HTLV; latency; RNA-FISH; gene burst; smFISH

Background : The human leukaemia virus HTLV-1 expresses essential accessory genes that manipulate the expression, splicing and transport of viral mRNAs.  Two of these genes, tax and hbz , also promote proliferation of the infected cell, and both genes are thought to contribute to oncogenesis in adul...