HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design

• Published in: Medicinal research reviews Vol. 33; no. S1; pp. E1 - E72
• Main Authors: Zhan, Peng, Chen, Xuwang, Li, Dongyue, Fang, Zengjun, De Clercq, Erik, Liu, Xinyong
• Format: Journal Article
• Language: English
• Published: Hoboken Blackwell Publishing Ltd 01.06.2013; Wiley Subscription Services, Inc
• Subjects: Chemistry; computational chemistry; crystallography; drug design; Drug resistance; HIV; HIV-1; Human immunodeficiency virus; medicinal chemistry; NNRTIs

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) nowadays represent very potent and most promising anti‐AIDS agents that specifically target the HIV‐1 reverse transcriptase (RT). However, the effectiveness of NNRTI drugs can be hampered by rapid emergence of drug‐resistant viruses and severe...