Efficacy and Safety of Single-dose Pegfilgrastim for CD34 + Cell Mobilization in Healthy Volunteers: A Phase 2 Study

• Published in: Transplantation Vol. 108; no. 4; p. 996
• Main Authors: Goto, Hideki, Sugita, Junichi, Hasegawa, Yuta, Hayasaka, Koji, Sunagoya, Kana, Hatase, Rie, Nishida, Mutsumi, Ichihashi, Yuki, Odera, Mitsuhiko, Senjo, Hajime, Yokoyama, Shota, Ara, Takahide, Shiratori, Souichi, Endo, Tomoyuki, Hino, Masayuki, Maeda, Yoshinobu, Sawa, Masashi, Sato, Norihiro, Teshima, Takanori
• Format: Journal Article
• Language: English
• Published: United States 01.04.2024
• Subjects: Antigens, CD34 - metabolism; Filgrastim - adverse effects; Granulocyte Colony-Stimulating Factor - adverse effects; Hematopoietic Stem Cell Mobilization; Humans; Polyethylene Glycols - adverse effects; Recombinant Proteins - adverse effects

Pegfilgrastim, a long-acting form of granulocyte-colony stimulating factor, with a convenient single-injection dosage, is being investigated for peripheral blood stem cell (PBSC) mobilization in healthy volunteers. However, data on the adequate dose of pegfilgrastim for PBSC mobilization are limited...