Anticancer activity of palladium-based complexes against triple-negative breast cancer

• Published in: Drug discovery today Vol. 24; no. 4; pp. 1044 - 1058
• Main Authors: Vojtek, Martin, Marques, Maria P.M., Ferreira, Isabel M.P.L.V.O., Mota-Filipe, Hélder, Diniz, Carmen
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2019
• Subjects: Antineoplastic Agents - therapeutic use; Female; Humans; Palladium - therapeutic use; Polyamines - therapeutic use; Triple Negative Breast Neoplasms - drug therapy

•TNBC is an unmet medical need with poor survival rates and no targeted therapy.•TNBC resists conventional chemotherapy and surgical strategies.•A review of 121 Pd(II) complexes studied in TNBC cell lines is presented.•Pd(II) complexes show promising cancer selectivity and activity against TNBC. Tre...