Dysregulation of hexosamine biosynthetic pathway wiring metabolic signaling circuits in cancer

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 1; p. 130250
• Main Authors: Itano, Naoki, Iwamoto, Shungo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2023
• Subjects: Acetylglucosamine - metabolism; Biological Phenomena; Biosynthetic Pathways; Cancer stem cells; Hexosamine biosynthetic pathway; Hexosamines - metabolism; Humans; Metabolic signaling; N-glycosylation; Neoplasms - metabolism; O-GlcNAcylation; Uridine Diphosphate; Ser; Hexosamine biosynthetic pathway; EGF; Gln; DLOs; N-glycosylation; EMT; ER; HBP; O-GlcNAcylation; HA; Cancer stem cells; Asn; Metabolic signaling; CSCs; Thr

Metabolite sensing, a fundamental biological process, plays a key role in metabolic signaling circuit rewiring. Hexosamine biosynthetic pathway (HBP) is a glucose metabolic pathway essential for the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which senses key nutrients and int...