Involvement of the GABA-B system in the mechanism of action of ultralow-dose antibodies to S-100 protein

• Published in: Bulletin of experimental biology and medicine Vol. 145; no. 5; pp. 614 - 616
• Main Authors: Kheifez, I. A., Molodavkin, G. M., Voronina, T. A., Dugina, Yu. L., Sergeeva, S. A., Epstein, O. I.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2008; Springer Nature B.V
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; Antibodies; Antibodies - administration & dosage; Antidepressants; Antidepressive Agents - pharmacology; Anxiety - drug therapy; Anxiety - etiology; Anxiety - immunology; Anxiolytics; Baclofen; Baclofen - pharmacology; Benzodiazepines; Biomedical and Life Sciences; Biomedicine; Cell Biology; Depression - drug therapy; Depression - etiology; Depression - immunology; Diazepam; Diazepam - pharmacology; Dose-Response Relationship, Immunologic; GABA Agonists - pharmacology; GABA Antagonists - pharmacology; Internal Medicine; Laboratory Medicine; Male; Pathology; Proteins; Rats; Receptors, GABA-B - immunology; S100 protein; S100 Proteins - antagonists & inhibitors; S100 Proteins - immunology; Tricyclic antidepressants; γ-Aminobutyric acid; γ-Aminobutyric acid B receptors; anxiety; depression; ultralow doses; GABAergic system; antibodies to S-100 proteins
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-008-0154-y

The involvement of the GABA-B neurotransmitter system in the realization of anxiolytic and antidepressant activities of ultralow-dose antibodies to S-100 protein is demonstrated. Simultaneous injection of ultralow-dose antibodies to S-100 protein and GABA-B receptor agonist baclofen reduced the anxiolytic and antidepressant effects of the drug, while GABA-B receptor antagonist faclofen stimulated the anxiolytic and reduced the antidepressant effect of ultralow-dose antibodies to S-100 protein. The effect of ultralow-dose antibodies to S-100 protein on the GABA-B-ergic system differs from that of benzodiazepine anxiolytics (diazepam) and tricyclic antidepressants (amitryptiline) not affecting this transmitter system.