The protective effect of recombinant globular adiponectin on testis by modulating autophagy, endoplasmic reticulum stress and oxidative stress in streptozotocin-induced diabetic mice

• Published in: European journal of pharmacology Vol. 879; p. 173132
• Main Authors: Shi, Wenjiao, Guo, Zhixin, Ji, Yun, Feng, Jingyi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.07.2020
• Subjects: Adiponectin; Adiponectin - genetics; Adiponectin - pharmacology; Adiponectin - therapeutic use; Animals; Autophagy; Autophagy - drug effects; Blood Glucose - drug effects; Diabetes; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - pathology; Endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Follicle Stimulating Hormone - blood; Insulin - blood; Lipids - blood; Luteinizing Hormone - blood; Male; Mice, Inbred C57BL; Oxidative stress; Oxidative Stress - drug effects; Protective Agents - pharmacology; Protective Agents - therapeutic use; Recombinant Proteins - pharmacology; Sperm Count; Testis; Testis - drug effects; Testis - pathology; Testosterone - blood; Testis; Oxidative stress; Diabetes; Autophagy; Adiponectin; Endoplasmic reticulum stress

This study was to investigate whether recombinant globular adiponectin produced its protective effect on the testis of diabetic mice by modulating autophagy, endoplasmic reticulum stress and oxidative stress. Male mice were randomly divided into control, diabetic, diabetic treated with low and high...