Pretreatment HIV Drug Resistance and HIV-1 Subtype C Are Independently Associated With Virologic Failure: Results From the Multinational PEARLS (ACTG A5175) Clinical Trial

• Published in: Clinical infectious diseases Vol. 60; no. 10; pp. 1541 - 1549
• Main Authors: Kantor, Rami, Smeaton, Laura, Vardhanabhuti, Saran, Hudelson, Sarah E., Wallis, Carol L., Tripathy, Srikanth, Morgado, Mariza G., Saravanan, Shanmugham, Balakrishnan, Pachamuthu, Reitsma, Marissa, Hart, Stephen, Mellors, John W., Halvas, Elias, Grinsztejn, Beatriz, Hosseinipour, Mina C., Kumwenda, Johnstone, La Rosa, Alberto, Lalloo, Umesh G., Lama, Javier R., Rassool, Mohammed, Santos, Breno R., Supparatpinyo, Khuanchai, Hakim, James, Flanigan, Timothy, Kumarasamy, Nagalingeswaran, Campbell, Thomas B., Eshleman, Susan H.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15.05.2015
• Subjects: Adolescent; Adult; Aged; Case-Control Studies; Clinical trials; Cohort Studies; Drug resistance; Drug Resistance, Viral; Failure; Female; Genotype; Genotype & phenotype; Genotyping Techniques; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - virology; HIV-1 - classification; HIV-1 - drug effects; HIV-1 - genetics; HIV-1 - isolation & purification; HIV/AIDS; Human immunodeficiency virus; Humans; Male; Medical treatment; Middle Aged; pol Gene Products, Human Immunodeficiency Virus - genetics; Randomized Controlled Trials as Topic; Treatment Failure; Viral Load; Young Adult; clinical trial; drug resistance; HIV; subtype

Background. Evaluation of pretreatment HIV genotyping is needed globally to guide treatment programs. We examined the association of pretreatment (baseline) drug resistance and subtype with virologic failure in a multinational, randomized clinical trial that evaluated 3 antiretroviral treatment (ART...