Suppression of miR-127 protects PC-12 cells from LPS-induced inflammatory injury by downregulation of PDCD4
Spinal cord injury (SCI) is one of the most debilitating injuries. Inflammatory response plays a central role in regulating the pathogenesis of acute and chronic SCI. Our study explores the role of miR-127 in inflammatory injury induced by LPS. PC-12 cells were treated with LPS to induce inflammator...
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| Published in | Biomedicine & pharmacotherapy Vol. 96; pp. 1154 - 1162 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
France
Elsevier Masson SAS
01.12.2017
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| Abstract | Spinal cord injury (SCI) is one of the most debilitating injuries. Inflammatory response plays a central role in regulating the pathogenesis of acute and chronic SCI. Our study explores the role of miR-127 in inflammatory injury induced by LPS. PC-12 cells were treated with LPS to induce inflammatory injury. The expression of miR-127 and PDCD4 was altered by transient transfection. Cell viability was measured using CCK-8 assay and apoptosis using flow cytometry. The expression of miR-127 was measured by qRT-PCR. The concentrations of TNF-α and IL-6 were detected by ELISA. The levels of TLR4, PDCD4, BCL6, core factors of JNK and NF-κB pathway were assessed by RT-PCR/western blot. Dual luciferase reporter assay was conducted to verify the relationship between miR-127 and BCL6. LPS induced inflammatory injury in PC-12 cells. LPS also increased the expression of miR-127 and PDCD4. miR-127 overexpression promoted the LPS-induced inflammatory injury while miR-127 suppression inhibited the injury. BCL6 was a target of miR-127 in PC-12 cells. In addition, miR-127 positively regulated PDCD4 expression, and PDCD4 showed a similar effect on LPS-induced injury in PC-12 cells. We also found that miR-127 and PDCD4 enhanced the activation of JNK and NF-κB pathway. Further, the expressions of miR-127 and PDCD4 were both upregulated in ASCI rats. Our present study demonstrated that miR-127 inhibition might exert a protective role in LPS-injured PC-12 cells through regulation of PDCD4 expression and the further downstream signaling pathway. |
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| AbstractList | Spinal cord injury (SCI) is one of the most debilitating injuries. Inflammatory response plays a central role in regulating the pathogenesis of acute and chronic SCI. Our study explores the role of miR-127 in inflammatory injury induced by LPS. PC-12 cells were treated with LPS to induce inflammatory injury. The expression of miR-127 and PDCD4 was altered by transient transfection. Cell viability was measured using CCK-8 assay and apoptosis using flow cytometry. The expression of miR-127 was measured by qRT-PCR. The concentrations of TNF-α and IL-6 were detected by ELISA. The levels of TLR4, PDCD4, BCL6, core factors of JNK and NF-κB pathway were assessed by RT-PCR/western blot. Dual luciferase reporter assay was conducted to verify the relationship between miR-127 and BCL6. LPS induced inflammatory injury in PC-12 cells. LPS also increased the expression of miR-127 and PDCD4. miR-127 overexpression promoted the LPS-induced inflammatory injury while miR-127 suppression inhibited the injury. BCL6 was a target of miR-127 in PC-12 cells. In addition, miR-127 positively regulated PDCD4 expression, and PDCD4 showed a similar effect on LPS-induced injury in PC-12 cells. We also found that miR-127 and PDCD4 enhanced the activation of JNK and NF-κB pathway. Further, the expressions of miR-127 and PDCD4 were both upregulated in ASCI rats. Our present study demonstrated that miR-127 inhibition might exert a protective role in LPS-injured PC-12 cells through regulation of PDCD4 expression and the further downstream signaling pathway. |
| Author | Zhang, Yinghua Wan, Faqing Zhang, Zaiqing Zhuang, Qingshan Xu, Zhaowan |
| Author_xml | – sequence: 1 givenname: Zaiqing surname: Zhang fullname: Zhang, Zaiqing email: zhangzaiqing81@126.com organization: Department of Orthopaedics, Linyi Central Hospital, Yishui, Shandong 276400, China – sequence: 2 givenname: Faqing surname: Wan fullname: Wan, Faqing organization: Department of Orthopaedics, Linyi Central Hospital, Yishui, Shandong 276400, China – sequence: 3 givenname: Qingshan surname: Zhuang fullname: Zhuang, Qingshan organization: Department of Spine Surgery, Weifang People’s Hospital, Weifang, Shandong 261041, China – sequence: 4 givenname: Yinghua surname: Zhang fullname: Zhang, Yinghua organization: Department of Orthopaedics, Linyi Central Hospital, Yishui, Shandong 276400, China – sequence: 5 givenname: Zhaowan surname: Xu fullname: Xu, Zhaowan organization: Department of Spine Surgery, Weifang People’s Hospital, Weifang, Shandong 261041, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29198922$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuroscience.2005.07.064 10.1016/j.bbrc.2005.09.036 10.1002/jnr.20345 10.1111/j.1460-9568.2006.05275.x 10.1016/j.acthis.2014.08.004 10.1016/j.freeradbiomed.2007.05.012 10.1016/S0092-8674(04)00045-5 10.3389/fnmol.2013.00043 10.1002/jnr.10215 10.1038/nrn1955 10.1016/S1529-9430(01)00029-8 10.1159/000358717 10.1111/j.1600-065X.2012.01112.x 10.1097/00002826-200109000-00002 10.1016/j.ccr.2006.04.020 10.1080/10790268.2004.11753769 10.1371/journal.pone.0080266 10.4049/jimmunol.1402088 10.1146/annurev.cellbio.21.122303.115827 10.1111/j.1471-4159.2009.05899.x 10.1007/s10571-009-9392-4 10.1080/10790268.2000.11753519 10.1089/neu.2008.0551 10.1042/bst0280551 10.1111/j.1745-7254.2007.00579.x 10.1016/S0006-291X(02)02129-0 10.4049/jimmunol.172.10.6345 10.1016/j.neulet.2006.01.031 10.1038/nature03147 10.1002/cne.21149 10.1111/j.1745-7254.2005.00152.x 10.18632/oncotarget.12680 10.1038/sj.jcbfm.9600412 10.1080/10715760902954126 10.1016/S1074-7613(00)00020-0 10.1101/gr.082701.108 10.1128/MCB.23.1.26-37.2003 10.4049/jimmunol.1101070 10.1016/j.brainresbull.2016.01.011 |
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| Keywords | miR-127 SCI PDCD4 Inflammation TLR4 LPS PC-12 Cells |
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| References | Habgood, Bye, Dziegielewska, Ek, Lane, Potter, Morganti-Kossmann, Saunders (bib0165) 2007; 25 Gál, Kravčuková, Mokrý, Kluchová (bib0105) 2009; 29 Akira (bib0130) 2000; 28 Lin, Vreman, Wong, Tjoa, Yamauchi, Noblehaeusslein (bib0020) 2007; 27 West, Koblansky, Ghosh (bib0135) 2006; 22 Wang, Li, Wang, Wang, Yao, Li (bib0075) 2014 Yang, Jansen, Komar, Zheng, Merrick, Costes, Lockett, Sonenberg, Colburn (bib0125) 2003; 23 Young (bib0015) 1993; 11 Shi, Kuai, Lei, Weng, Siebelt, Zhang, Wang, Zhou, Jiang, Ren (bib0180) 2016; 7 Friedman, Farh, Burge, Bartel (bib0060) 2008; 19 Campagnolo, Bartlett, Keller (bib0005) 2000; 23 Genovese, Esposito, Mazzon, Paola, Caminiti, Bramanti, Cappelani, Cuzzocrea (bib0090) 2009; 108 Xie, Liang, Liu, Wang, Li, Noble, Jiang (bib0085) 2012; 188 Pannu, Barbosa, Singh, Singh (bib0110) 2005; 79 Zhou, Lu, Yang, Chen, Shi, Miao, Jiao (bib0070) 2014; 33 Saito, Liang, Egger, Friedman, Chuang, Coetzee, Jones (bib0155) 2006; 9 Wang, Kong, Wei-Li, Wei-Lian (bib0115) 2005; 26 Tsuyama, Danjoh, Otsuyama, Obata, Tahara, Ohta, Ishikawa (bib0160) 2005; 337 Pineau, Lacroix (bib0170) 2007; 500 Genovese, Mazzon, Esposito, Muià, Di, Bramanti, Cuzzocrea (bib0025) 2007; 43 Zu, Wang, Xu, Zhuang, Gong, Yan (bib0145) 2014; 116 Wu, Ren (bib0010) 2009; 26 Xu, An, Xi, Li, Li, Liang, Zhu, Yang (bib0150) 2016; 121 Pearson, Byrne, MacGibbon, Faull, Dragunow (bib0205) 2006; 398 Basso, Dallafavera (bib0195) 2012; 247 Lammertse (bib0100) 2004; 27 Thuret, Moon, Gage (bib0035) 2006; 7 Göke, Göke, Knolle, Trusheim, Schmidt, Wilmen, Carmody, Göke, Chen (bib0120) 2002; 297 Chen, Wang, Guo, Xie, Cong (bib0080) 2013; 8 Rothfuchs, Trumstedt, Wigzell, Rottenberg (bib0140) 2004; 172 Phan, Dalla-Favera (bib0190) 2004; 432 Whalley, O'Neill, Ferretti (bib0045) 2006; 137 Bartel (bib0055) 2004; 116 Pan, Ni, Sodhi, Aguanno, Young, Hart (bib0095) 2002; 68 Dumont, Okonkwo, Verma, Hurlbert, Boulos, Ellegala, Dumont (bib0040) 2001; 24 Ying, Kang, Zhang, Zhao, Xia, Lu, Wang, Xu, Shi (bib0175) 2015; 194 Genovese, Mazzon, Esposito, Di, Murthy, Neville, Bramanti, Cuzzocrea (bib0030) 2009; 43 Shaffer, Yu, He, Boldrick, Chan, Staudt (bib0185) 2000; 13 Cui, Zhang, Zhang, Xu (bib0200) 2007; 28 Carlson, Gorden (bib0050) 2002; 2 Khudayberdiev, Federico, Marek, Gerhard (bib0065) 2013; 6 Thuret (10.1016/j.biopha.2017.11.107_bib0035) 2006; 7 Gál (10.1016/j.biopha.2017.11.107_bib0105) 2009; 29 Dumont (10.1016/j.biopha.2017.11.107_bib0040) 2001; 24 Bartel (10.1016/j.biopha.2017.11.107_bib0055) 2004; 116 Wang (10.1016/j.biopha.2017.11.107_bib0115) 2005; 26 Habgood (10.1016/j.biopha.2017.11.107_bib0165) 2007; 25 Yang (10.1016/j.biopha.2017.11.107_bib0125) 2003; 23 Shaffer (10.1016/j.biopha.2017.11.107_bib0185) 2000; 13 Saito (10.1016/j.biopha.2017.11.107_bib0155) 2006; 9 Genovese (10.1016/j.biopha.2017.11.107_bib0030) 2009; 43 Göke (10.1016/j.biopha.2017.11.107_bib0120) 2002; 297 Ying (10.1016/j.biopha.2017.11.107_bib0175) 2015; 194 Pannu (10.1016/j.biopha.2017.11.107_bib0110) 2005; 79 Chen (10.1016/j.biopha.2017.11.107_bib0080) 2013; 8 Xu (10.1016/j.biopha.2017.11.107_bib0150) 2016; 121 Carlson (10.1016/j.biopha.2017.11.107_bib0050) 2002; 2 Lin (10.1016/j.biopha.2017.11.107_bib0020) 2007; 27 Young (10.1016/j.biopha.2017.11.107_bib0015) 1993; 11 Genovese (10.1016/j.biopha.2017.11.107_bib0090) 2009; 108 Whalley (10.1016/j.biopha.2017.11.107_bib0045) 2006; 137 Wang (10.1016/j.biopha.2017.11.107_bib0075) 2014 Phan (10.1016/j.biopha.2017.11.107_bib0190) 2004; 432 Zu (10.1016/j.biopha.2017.11.107_bib0145) 2014; 116 Xie (10.1016/j.biopha.2017.11.107_bib0085) 2012; 188 Lammertse (10.1016/j.biopha.2017.11.107_bib0100) 2004; 27 Friedman (10.1016/j.biopha.2017.11.107_bib0060) 2008; 19 Pan (10.1016/j.biopha.2017.11.107_bib0095) 2002; 68 Genovese (10.1016/j.biopha.2017.11.107_bib0025) 2007; 43 Akira (10.1016/j.biopha.2017.11.107_bib0130) 2000; 28 Zhou (10.1016/j.biopha.2017.11.107_bib0070) 2014; 33 Khudayberdiev (10.1016/j.biopha.2017.11.107_bib0065) 2013; 6 Cui (10.1016/j.biopha.2017.11.107_bib0200) 2007; 28 Campagnolo (10.1016/j.biopha.2017.11.107_bib0005) 2000; 23 Rothfuchs (10.1016/j.biopha.2017.11.107_bib0140) 2004; 172 Pineau (10.1016/j.biopha.2017.11.107_bib0170) 2007; 500 Shi (10.1016/j.biopha.2017.11.107_bib0180) 2016; 7 Basso (10.1016/j.biopha.2017.11.107_bib0195) 2012; 247 Pearson (10.1016/j.biopha.2017.11.107_bib0205) 2006; 398 West (10.1016/j.biopha.2017.11.107_bib0135) 2006; 22 Tsuyama (10.1016/j.biopha.2017.11.107_bib0160) 2005; 337 Wu (10.1016/j.biopha.2017.11.107_bib0010) 2009; 26 |
| References_xml | – volume: 43 start-page: 631 year: 2009 ident: bib0030 article-title: Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury publication-title: Free Radical Res. contributor: fullname: Cuzzocrea – volume: 116 start-page: 281 year: 2004 end-page: 297 ident: bib0055 article-title: MicroRNAs: genomics, biogenesis, mechanism, and function publication-title: Cell contributor: fullname: Bartel – volume: 27 start-page: 1010 year: 2007 end-page: 1021 ident: bib0020 article-title: Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord publication-title: J. Cereb. Blood Flow Metab. contributor: fullname: Noblehaeusslein – volume: 33 start-page: 1537 year: 2014 end-page: 1546 ident: bib0070 article-title: MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells publication-title: Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol. contributor: fullname: Jiao – volume: 194 start-page: 1239 year: 2015 ident: bib0175 article-title: MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway publication-title: J. Immunol. contributor: fullname: Shi – volume: 2 start-page: 116 year: 2002 ident: bib0050 article-title: Current developments in spinal cord injury research publication-title: Spine J. contributor: fullname: Gorden – volume: 108 start-page: 1360 year: 2009 end-page: 1372 ident: bib0090 article-title: Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice publication-title: J. Neurochem. contributor: fullname: Cuzzocrea – volume: 68 start-page: 315 year: 2002 end-page: 322 ident: bib0095 article-title: Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion publication-title: J. Neurosci. Res. contributor: fullname: Hart – volume: 23 start-page: 26 year: 2003 end-page: 37 ident: bib0125 article-title: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation publication-title: Mol. Cell. Biol. contributor: fullname: Colburn – volume: 137 start-page: 821 year: 2006 ident: bib0045 article-title: Changes in response to spinal cord injury with development: vascularization, hemorrhage and apoptosis publication-title: Neuroscience contributor: fullname: Ferretti – volume: 28 start-page: 551 year: 2000 ident: bib0130 article-title: Toll-like receptors: lessons from knockout mice publication-title: Biochem. Soc. Trans. contributor: fullname: Akira – volume: 500 start-page: 267 year: 2007 ident: bib0170 article-title: Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved publication-title: J. Comp. Neurol. contributor: fullname: Lacroix – volume: 79 start-page: 340 year: 2005 end-page: 350 ident: bib0110 article-title: Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats publication-title: J. Neurosci. Res. contributor: fullname: Singh – volume: 22 start-page: 409 year: 2006 ident: bib0135 article-title: Recognition and signaling by toll-like receptors publication-title: Ann. Rev. Cell Dev. Biol. contributor: fullname: Ghosh – volume: 247 start-page: 172 year: 2012 ident: bib0195 article-title: Roles of BCL6 in normal and transformed germinal center B cells publication-title: Immunol. Rev. contributor: fullname: Dallafavera – volume: 26 start-page: 1847 year: 2009 end-page: 1856 ident: bib0010 article-title: Promoting axonal myelination for improving neurological recovery in spinal cord injury publication-title: J. Neurotrauma contributor: fullname: Ren – volume: 28 start-page: 601 year: 2007 end-page: 608 ident: bib0200 article-title: JNK pathway: diseases and therapeutic potential publication-title: Acta Pharmacol. Sin. contributor: fullname: Xu – volume: 188 start-page: 2437 year: 2012 ident: bib0085 article-title: miRNA-127 Inhibits lung inflammation by targeting IgG Fcγ receptor I publication-title: J. Immunol. contributor: fullname: Jiang – volume: 25 start-page: 231 year: 2007 end-page: 238 ident: bib0165 article-title: Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice publication-title: Eur. J. Neurosci. contributor: fullname: Saunders – volume: 172 start-page: 6345 year: 2004 ident: bib0140 article-title: Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling publication-title: J. Immunol. contributor: fullname: Rottenberg – volume: 337 start-page: 201 year: 2005 end-page: 208 ident: bib0160 article-title: IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Ishikawa – volume: 19 start-page: 92 year: 2008 end-page: 105 ident: bib0060 article-title: Most mammalian mRNAs are conserved targets of microRNAs publication-title: Genome Res. contributor: fullname: Bartel – volume: 116 start-page: 1331 year: 2014 ident: bib0145 article-title: Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by inhibiting the JAK/STAT signaling pathway publication-title: Acta Histochem. contributor: fullname: Yan – volume: 11 start-page: 13 year: 1993 end-page: 22 ident: bib0015 article-title: Secondary injury mechanisms in acute spinal cord injury publication-title: J. Emerg. Med. contributor: fullname: Young – volume: 43 start-page: 763 year: 2007 end-page: 780 ident: bib0025 article-title: Beneficial effects of FeTSPP, a peroxynitrite decomposition catalyst, in a mouse model of spinal cord injury publication-title: Free Radical Biol. Med. contributor: fullname: Cuzzocrea – volume: 6 start-page: 43 year: 2013 ident: bib0065 article-title: A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons publication-title: Front. Mol. Neurosci. contributor: fullname: Gerhard – volume: 26 start-page: 934 year: 2005 end-page: 942 ident: bib0115 article-title: Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury publication-title: Acta Pharmacol. Sin contributor: fullname: Wei-Lian – start-page: 401986 year: 2014 ident: bib0075 article-title: Prognostic and biological significance of microRNA-127 expression in human breast cancer publication-title: Dis. Markers 2014 contributor: fullname: Li – volume: 432 start-page: 635 year: 2004 end-page: 639 ident: bib0190 article-title: The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells publication-title: Nature contributor: fullname: Dalla-Favera – volume: 24 start-page: 254 year: 2001 end-page: 264 ident: bib0040 article-title: Acute spinal cord injury, part I: pathophysiologic mechanisms publication-title: Clin. Neuropharmacol. contributor: fullname: Dumont – volume: 8 start-page: e80266 year: 2013 ident: bib0080 article-title: miR-127 Regulates cell proliferation and senescence by targeting BCL6 publication-title: PLoS One contributor: fullname: Cong – volume: 29 start-page: 1025 year: 2009 end-page: 1035 ident: bib0105 article-title: Chemokines as possible targets in modulation of the secondary damage after acute spinal cord injury: a review publication-title: Cell. Mol. Neurobiol. contributor: fullname: Kluchová – volume: 121 start-page: 233 year: 2016 end-page: 240 ident: bib0150 article-title: MicroRNA-9 controls apoptosis of neurons by targeting monocyte chemotactic protein-induced protein 1 expression in rat acute spinal cord injury model publication-title: Brain Res. Bull. contributor: fullname: Yang – volume: 398 start-page: 246 year: 2006 end-page: 250 ident: bib0205 article-title: Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains publication-title: Neurosci. Lett. contributor: fullname: Dragunow – volume: 9 start-page: 435 year: 2006 ident: bib0155 article-title: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells publication-title: Cancer Cell contributor: fullname: Jones – volume: 13 start-page: 199 year: 2000 end-page: 212 ident: bib0185 article-title: BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control publication-title: Immunity contributor: fullname: Staudt – volume: 7 start-page: 628 year: 2006 end-page: 643 ident: bib0035 article-title: Therapeutic interventions after spinal cord injury publication-title: Nat. Rev. Neurosci. contributor: fullname: Gage – volume: 7 start-page: 77444 year: 2016 end-page: 77456 ident: bib0180 article-title: The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin's-lymphoma publication-title: Oncotarget contributor: fullname: Ren – volume: 297 start-page: 78 year: 2002 end-page: 82 ident: bib0120 article-title: DUG is a novel homologue of translation initiation factor 4G that binds eIF4A publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Chen – volume: 23 start-page: 121 year: 2000 ident: bib0005 article-title: Influence of neurological level on immune function following spinal cord injury: a review publication-title: J. Spinal Cord Med. contributor: fullname: Keller – volume: 27 start-page: 319 year: 2004 ident: bib0100 article-title: Update on pharmaceutical trials in acute spinal cord injury publication-title: J. Spinal Cord Med. contributor: fullname: Lammertse – volume: 137 start-page: 821 issue: 3 year: 2006 ident: 10.1016/j.biopha.2017.11.107_bib0045 article-title: Changes in response to spinal cord injury with development: vascularization, hemorrhage and apoptosis publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.07.064 contributor: fullname: Whalley – volume: 337 start-page: 201 issue: 1 year: 2005 ident: 10.1016/j.biopha.2017.11.107_bib0160 article-title: IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2005.09.036 contributor: fullname: Tsuyama – volume: 79 start-page: 340 issue: 3 year: 2005 ident: 10.1016/j.biopha.2017.11.107_bib0110 article-title: Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats publication-title: J. Neurosci. Res. doi: 10.1002/jnr.20345 contributor: fullname: Pannu – volume: 25 start-page: 231 issue: 1 year: 2007 ident: 10.1016/j.biopha.2017.11.107_bib0165 article-title: Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2006.05275.x contributor: fullname: Habgood – volume: 116 start-page: 1331 issue: 8 year: 2014 ident: 10.1016/j.biopha.2017.11.107_bib0145 article-title: Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by inhibiting the JAK/STAT signaling pathway publication-title: Acta Histochem. doi: 10.1016/j.acthis.2014.08.004 contributor: fullname: Zu – volume: 43 start-page: 763 issue: 5 year: 2007 ident: 10.1016/j.biopha.2017.11.107_bib0025 article-title: Beneficial effects of FeTSPP, a peroxynitrite decomposition catalyst, in a mouse model of spinal cord injury publication-title: Free Radical Biol. Med. doi: 10.1016/j.freeradbiomed.2007.05.012 contributor: fullname: Genovese – volume: 116 start-page: 281 year: 2004 ident: 10.1016/j.biopha.2017.11.107_bib0055 article-title: MicroRNAs: genomics, biogenesis, mechanism, and function publication-title: Cell doi: 10.1016/S0092-8674(04)00045-5 contributor: fullname: Bartel – volume: 6 start-page: 43 year: 2013 ident: 10.1016/j.biopha.2017.11.107_bib0065 article-title: A comprehensive characterization of the nuclear microRNA repertoire of post-mitotic neurons publication-title: Front. Mol. Neurosci. doi: 10.3389/fnmol.2013.00043 contributor: fullname: Khudayberdiev – volume: 68 start-page: 315 issue: 3 year: 2002 ident: 10.1016/j.biopha.2017.11.107_bib0095 article-title: Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion publication-title: J. Neurosci. Res. doi: 10.1002/jnr.10215 contributor: fullname: Pan – volume: 7 start-page: 628 issue: 8 year: 2006 ident: 10.1016/j.biopha.2017.11.107_bib0035 article-title: Therapeutic interventions after spinal cord injury publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn1955 contributor: fullname: Thuret – volume: 2 start-page: 116 issue: 2 year: 2002 ident: 10.1016/j.biopha.2017.11.107_bib0050 article-title: Current developments in spinal cord injury research publication-title: Spine J. doi: 10.1016/S1529-9430(01)00029-8 contributor: fullname: Carlson – start-page: 401986 year: 2014 ident: 10.1016/j.biopha.2017.11.107_bib0075 article-title: Prognostic and biological significance of microRNA-127 expression in human breast cancer publication-title: Dis. Markers 2014 contributor: fullname: Wang – volume: 33 start-page: 1537 issue: 5 year: 2014 ident: 10.1016/j.biopha.2017.11.107_bib0070 article-title: MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells publication-title: Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol. doi: 10.1159/000358717 contributor: fullname: Zhou – volume: 247 start-page: 172 issue: 1 year: 2012 ident: 10.1016/j.biopha.2017.11.107_bib0195 article-title: Roles of BCL6 in normal and transformed germinal center B cells publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2012.01112.x contributor: fullname: Basso – volume: 24 start-page: 254 issue: 5 year: 2001 ident: 10.1016/j.biopha.2017.11.107_bib0040 article-title: Acute spinal cord injury, part I: pathophysiologic mechanisms publication-title: Clin. Neuropharmacol. doi: 10.1097/00002826-200109000-00002 contributor: fullname: Dumont – volume: 9 start-page: 435 issue: 6 year: 2006 ident: 10.1016/j.biopha.2017.11.107_bib0155 article-title: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.04.020 contributor: fullname: Saito – volume: 27 start-page: 319 issue: 4 year: 2004 ident: 10.1016/j.biopha.2017.11.107_bib0100 article-title: Update on pharmaceutical trials in acute spinal cord injury publication-title: J. Spinal Cord Med. doi: 10.1080/10790268.2004.11753769 contributor: fullname: Lammertse – volume: 8 start-page: e80266 issue: 11 year: 2013 ident: 10.1016/j.biopha.2017.11.107_bib0080 article-title: miR-127 Regulates cell proliferation and senescence by targeting BCL6 publication-title: PLoS One doi: 10.1371/journal.pone.0080266 contributor: fullname: Chen – volume: 194 start-page: 1239 issue: 3 year: 2015 ident: 10.1016/j.biopha.2017.11.107_bib0175 article-title: MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway publication-title: J. Immunol. doi: 10.4049/jimmunol.1402088 contributor: fullname: Ying – volume: 22 start-page: 409 issue: 1 year: 2006 ident: 10.1016/j.biopha.2017.11.107_bib0135 article-title: Recognition and signaling by toll-like receptors publication-title: Ann. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.21.122303.115827 contributor: fullname: West – volume: 108 start-page: 1360 issue: 6 year: 2009 ident: 10.1016/j.biopha.2017.11.107_bib0090 article-title: Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2009.05899.x contributor: fullname: Genovese – volume: 29 start-page: 1025 issue: 6–7 year: 2009 ident: 10.1016/j.biopha.2017.11.107_bib0105 article-title: Chemokines as possible targets in modulation of the secondary damage after acute spinal cord injury: a review publication-title: Cell. Mol. Neurobiol. doi: 10.1007/s10571-009-9392-4 contributor: fullname: Gál – volume: 23 start-page: 121 issue: 2 year: 2000 ident: 10.1016/j.biopha.2017.11.107_bib0005 article-title: Influence of neurological level on immune function following spinal cord injury: a review publication-title: J. Spinal Cord Med. doi: 10.1080/10790268.2000.11753519 contributor: fullname: Campagnolo – volume: 26 start-page: 1847 issue: 10 year: 2009 ident: 10.1016/j.biopha.2017.11.107_bib0010 article-title: Promoting axonal myelination for improving neurological recovery in spinal cord injury publication-title: J. Neurotrauma doi: 10.1089/neu.2008.0551 contributor: fullname: Wu – volume: 28 start-page: 551 issue: 5 year: 2000 ident: 10.1016/j.biopha.2017.11.107_bib0130 article-title: Toll-like receptors: lessons from knockout mice publication-title: Biochem. Soc. Trans. doi: 10.1042/bst0280551 contributor: fullname: Akira – volume: 28 start-page: 601 issue: 5 year: 2007 ident: 10.1016/j.biopha.2017.11.107_bib0200 article-title: JNK pathway: diseases and therapeutic potential publication-title: Acta Pharmacol. Sin. doi: 10.1111/j.1745-7254.2007.00579.x contributor: fullname: Cui – volume: 11 start-page: 13 issue: Suppl 1 (10) year: 1993 ident: 10.1016/j.biopha.2017.11.107_bib0015 article-title: Secondary injury mechanisms in acute spinal cord injury publication-title: J. Emerg. Med. contributor: fullname: Young – volume: 297 start-page: 78 issue: 1 year: 2002 ident: 10.1016/j.biopha.2017.11.107_bib0120 article-title: DUG is a novel homologue of translation initiation factor 4G that binds eIF4A publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(02)02129-0 contributor: fullname: Göke – volume: 172 start-page: 6345 issue: 10 year: 2004 ident: 10.1016/j.biopha.2017.11.107_bib0140 article-title: Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling publication-title: J. Immunol. doi: 10.4049/jimmunol.172.10.6345 contributor: fullname: Rothfuchs – volume: 398 start-page: 246 issue: 3 year: 2006 ident: 10.1016/j.biopha.2017.11.107_bib0205 article-title: Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2006.01.031 contributor: fullname: Pearson – volume: 432 start-page: 635 issue: 7017 year: 2004 ident: 10.1016/j.biopha.2017.11.107_bib0190 article-title: The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells publication-title: Nature doi: 10.1038/nature03147 contributor: fullname: Phan – volume: 500 start-page: 267 issue: 2 year: 2007 ident: 10.1016/j.biopha.2017.11.107_bib0170 article-title: Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved publication-title: J. Comp. Neurol. doi: 10.1002/cne.21149 contributor: fullname: Pineau – volume: 26 start-page: 934 issue: 8 year: 2005 ident: 10.1016/j.biopha.2017.11.107_bib0115 article-title: Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury publication-title: Acta Pharmacol. Sin doi: 10.1111/j.1745-7254.2005.00152.x contributor: fullname: Wang – volume: 7 start-page: 77444 issue: 47 year: 2016 ident: 10.1016/j.biopha.2017.11.107_bib0180 article-title: The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin's-lymphoma publication-title: Oncotarget doi: 10.18632/oncotarget.12680 contributor: fullname: Shi – volume: 27 start-page: 1010 issue: 5 year: 2007 ident: 10.1016/j.biopha.2017.11.107_bib0020 article-title: Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/sj.jcbfm.9600412 contributor: fullname: Lin – volume: 43 start-page: 631 issue: 7 year: 2009 ident: 10.1016/j.biopha.2017.11.107_bib0030 article-title: Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury publication-title: Free Radical Res. doi: 10.1080/10715760902954126 contributor: fullname: Genovese – volume: 13 start-page: 199 issue: 2 year: 2000 ident: 10.1016/j.biopha.2017.11.107_bib0185 article-title: BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control publication-title: Immunity doi: 10.1016/S1074-7613(00)00020-0 contributor: fullname: Shaffer – volume: 19 start-page: 92 issue: 1 year: 2008 ident: 10.1016/j.biopha.2017.11.107_bib0060 article-title: Most mammalian mRNAs are conserved targets of microRNAs publication-title: Genome Res. doi: 10.1101/gr.082701.108 contributor: fullname: Friedman – volume: 23 start-page: 26 issue: 1 year: 2003 ident: 10.1016/j.biopha.2017.11.107_bib0125 article-title: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.1.26-37.2003 contributor: fullname: Yang – volume: 188 start-page: 2437 issue: 5 year: 2012 ident: 10.1016/j.biopha.2017.11.107_bib0085 article-title: miRNA-127 Inhibits lung inflammation by targeting IgG Fcγ receptor I publication-title: J. Immunol. doi: 10.4049/jimmunol.1101070 contributor: fullname: Xie – volume: 121 start-page: 233 year: 2016 ident: 10.1016/j.biopha.2017.11.107_bib0150 article-title: MicroRNA-9 controls apoptosis of neurons by targeting monocyte chemotactic protein-induced protein 1 expression in rat acute spinal cord injury model publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2016.01.011 contributor: fullname: Xu |
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