Infection of the germ line by retroviral particles produced in the follicle cells: a possible mechanism for the mobilization of the gypsy retroelement of Drosophila

• Published in: Development (Cambridge) Vol. 124; no. 14; pp. 2789 - 2798
• Main Authors: Song, S U, Kurkulos, M, Boeke, J D, Corces, V G
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.07.1997
• Subjects: Animals; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - virology; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Viral; Gene Products, env; Gene Products, pol; Insect Proteins - physiology; Membrane Proteins - metabolism; Oocytes - virology; Oogenesis; Open Reading Frames; Ovary - metabolism; Retroelements; Retroviridae Proteins - metabolism; RNA, Viral - metabolism; Virion - metabolism

The gypsy retroelement of Drosophila moves at high frequency in the germ line of the progeny of females carrying a mutation in the flamenco (flam) gene. This high rate of de novo insertion correlates with elevated accumulation of full-length gypsy RNA in the ovaries of these females, as well as the...