A rapid, reliable, and valid method for measuring infarct and brain compartment volumes from computed tomographic scans

• Published in: Stroke (1970) Vol. 25; no. 12; pp. 2421 - 2428
• Main Authors: Lyden, P D, Zweifler, R, Mahdavi, Z, Lonzo, L
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.12.1994
• Subjects: Aged; Biological and medical sciences; Brain - diagnostic imaging; Brain Stem - diagnostic imaging; Case-Control Studies; Cerebellum - diagnostic imaging; Cerebral Cortex - diagnostic imaging; Cerebral Infarction - diagnostic imaging; Cerebral Ventriculography; Cerebrospinal Fluid; Cerebrovascular Disorders - diagnostic imaging; Clinical Trials as Topic; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Multicenter Studies as Topic; Nervous system; Observer Variation; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiographic Image Enhancement; Reproducibility of Results; Skull - diagnostic imaging; Stereotaxic Techniques; Tomography, X-Ray Computed; Human; Cerebral infarction; Volumetric analysis; Nervous system diseases; Radiodiagnosis; Standardization; Cardiovascular disease; Cerebral disorder; Vascular disease; Central nervous system disease; Computerized axial tomography; Measurement method; Morphometry; Cerebrovascular disease

Clinical stroke trials require objective and reproducible end point variables. Morphometry of cerebral structures, including infarct volume, provides numerical measures that represent the amount of tissue damaged and potentially salvaged by therapy. However, morphometry may be time-consuming and lab...