DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

• Published in: Drug discovery today Vol. 21; no. 4; pp. 648 - 653
• Main Authors: Chen, Minjun, Suzuki, Ayako, Thakkar, Shraddha, Yu, Ke, Hu, Chuchu, Tong, Weida
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2016
• Subjects: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations - classification; Risk

•DILIrank contains the largest number of drugs (N=1036) ranked by their risk for causing DILI.•The existing drug labeling-based DILI annotation was enhanced by weighing evidence of causality.•Drugs were classified as verified vMost-, vLess-, vNo-DILI-concern, leaving out terminology ‘Ambiguous DILI-...