Array CGH in patients with learning disability (mental retardation) and congenital anomalies: updated systematic review and meta-analysis of 19 studies and 13,926 subjects

• Published in: Genetics in medicine Vol. 11; no. 3; pp. 139 - 146
• Main Authors: Sagoo, Gurdeep S, Butterworth, Adam S, Sanderson, Simon, Shaw-Smith, Charles, Higgins, Julian P T, Burton, Hilary
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2009
• Subjects: Biomedical and Life Sciences; Biomedicine; Comparative Genomic Hybridization - methods; Congenital Abnormalities - diagnosis; Congenital Abnormalities - genetics; Human Genetics; Humans; Intellectual Disability - diagnosis; Intellectual Disability - genetics; Laboratory Medicine; Reproducibility of Results; review; Sensitivity and Specificity; mental retardation; learning disability; array-based comparative genomic hybridization; genetic testing; microarrays

: Array-based comparative genomic hybridization is being increasingly used in patients with learning disability (mental retardation) and congenital anomalies. In this article, we update our previous meta-analysis evaluating the diagnostic and false-positive yields of this technology. An updated syst...