HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis

• Published in: Biochemical and biophysical research communications Vol. 496; no. 3; pp. 904 - 910
• Main Authors: Cheng, Sheng-Tao, Ren, Ji-Hua, Cai, Xue-Fei, Jiang, Hui, Chen, Juan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.02.2018
• Subjects: 60 APPLIED LIFE SCIENCES; Adaptor Proteins, Signal Transducing - metabolism; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Line, Tumor; HBx; HCC; Hepatitis B - metabolism; Hepatitis B - virology; Hepatitis B virus - physiology; HISTONES; Humans; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms - virology; MESSENGER-RNA; SIRT2; Sirtuin 2 - metabolism; TRANSCRIPTION; Virus Replication - physiology; HCC; SIRT2; HBx

Sirtuin 2 (SIRT2) is a class III histone deacetylase that has been implicated to promote HCC development. However, the functional role of SIRT2 in HBV is still unclear. In this study, we found that HBV could upregulate SIRT2 expression. Additionally, HBx could activate SIRT2 promoter to upregulate t...