Trimellitic anhydride facilitates transepithelial permeability disrupting tight junctions in sinonasal epithelial cells

• Published in: Toxicology letters Vol. 353; pp. 27 - 33
• Main Authors: Ogi, Kazuhiro, Liu, Sha, Ramezanpour, Mahnaz, Cooksley, Clare, Javadiyan, Shari, Fujieda, Shigeharu, Wormald, Peter-John, Vreugde, Sarah, Psaltis, Alkis James
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2021
• Subjects: Adult; Air liquid interface cell culture; Cell Survival - drug effects; Claudin-1 - genetics; Claudin-1 - metabolism; Dextrans; Dose-Response Relationship, Drug; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Female; Fluorescein-5-isothiocyanate - analogs & derivatives; Fluorescent Antibody Technique, Direct; Gene Expression Regulation - drug effects; Humans; Male; Middle Aged; Nose - cytology; Occupational rhinitis; Permeability; Phthalic Anhydrides - administration & dosage; Phthalic Anhydrides - toxicity; Tight junctions; Trimellitic anhydride; Zonula Occludens-1 Protein - genetics; Zonula Occludens-1 Protein - metabolism; RT; HNEC; IgE; LDH; MFI; FITC; OA; ANOVA; Occupational rhinitis; PBS; OR; SDS; Air liquid interface cell culture; Tight junctions; DAPI; TMA; TRPV1; HMW; ZO; PEL; TJ; LMW; TEER; SEM; RPMI; Trimellitic anhydride; ALI

[Display omitted] •TMA attenuates transepithelial electrical resistance and increases paracellular permeability.•ZO-1 and claudin-1 are disrupted by TMA in a dose-dependent manner.•Trimellitic anhydride shows cytotoxicity only after prolonged incubation. Trimellitic anhydride (TMA) is a chemical age...