Tumor Necrosis Factor/Cachectin and Lymphotoxin Gene Expression in Lymph Nodes From Lymphoma Patients

• Published in: Blood Vol. 75; no. 4; pp. 958 - 962
• Main Authors: Sappino, André-Pascal, Seelentag, Walter, Pelte, Marie-Françoise, Alberto, Pierre, Vassalli, Pierre
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 15.02.1990; The Americain Society of Hematology
• Subjects: Biological and medical sciences; Blotting, Northern; Gene Expression; Hematologic and hematopoietic diseases; Hodgkin Disease - metabolism; Hodgkin Disease - pathology; Humans; Interleukin-1 - genetics; Interleukin-1 - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphoma, Non-Hodgkin - metabolism; Lymphoma, Non-Hodgkin - pathology; Lymphotoxin-alpha - genetics; Lymphotoxin-alpha - metabolism; Medical sciences; RNA Probes; RNA, Messenger - genetics; RNA, Messenger - metabolism; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Human; Lymphotoxin; Northern blotting; Messenger RNA; Lymph node; Pathophysiology; Tumor necrosis factor; Cytokine; Hodgkin disease; Malignant hemopathy; Gene expression; Non Hodgkin lymphoma

We investigated the mRNA content for tumor necrosis factor (TNF)/cachectin and lymphotoxin (LT) in tumoral tissues of a prospective series of 35 non-Hodgkin's (NHL) and 23 Hodgkin's (HL) lymphomas, to assess their postulated contribution to systemic symptoms. Total RNAs were extracted from...