Antitumor effects of somatostatin
Since its discovery three decades ago as an inhibitor of GH release from the pituitary gland, somatostatin has attracted much attention because of its functional role in the regulation of a wide variety of physiological functions in the brain, pituitary, pancreas, gastrointestinal tract, adrenals, t...
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| Published in | Molecular and cellular endocrinology Vol. 286; no. 1; pp. 230 - 237 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier Ireland Ltd
14.05.2008
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0303-7207 1872-8057 1872-8057 0303-7207 |
| DOI | 10.1016/j.mce.2008.02.002 |
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| Abstract | Since its discovery three decades ago as an inhibitor of GH release from the pituitary gland, somatostatin has attracted much attention because of its functional role in the regulation of a wide variety of physiological functions in the brain, pituitary, pancreas, gastrointestinal tract, adrenals, thyroid, kidney and immune system. In addition to its negative role in the control of endocrine and exocrine secretions, somatostatin and analogs also exert inhibitory effects on the proliferation and survival of normal and tumor cells. Over the past 15 years, studies have begun to reveal some of the molecular mechanisms underlying the antitumor activity of somatostatin. This review covers the present knowledge in the antitumor effect of somatostatin and analogs and discusses the perspectives of novel clinical strategies based on somatostatin receptor sst2 gene transfer therapy. |
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| AbstractList | Since its discovery three decades ago as an inhibitor of GH release from the pituitary gland, somatostatin has attracted much attention because of its functional role in the regulation of a wide variety of physiological functions in the brain, pituitary, pancreas, gastrointestinal tract, adrenals, thyroid, kidney and immune system. In addition to its negative role in the control of endocrine and exocrine secretions, somatostatin and analogs also exert inhibitory effects on the proliferation and survival of normal and tumor cells. Over the past 15 years, studies have begun to reveal some of the molecular mechanisms underlying the antitumor activity of somatostatin. This review covers the present knowledge in the antitumor effect of somatostatin and analogs and discusses the perspectives of novel clinical strategies based on somatostatin receptor sst2 gene transfer therapy. Since its discovery three decades ago as an inhibitor of GH release from the pituitary gland, somatostatin has attracted much attention because of its functional role in the regulation of a wide variety of physiological functions in the brain, pituitary, pancreas, gastrointestinal tract, adrenals, thyroid, kidney and immune system. In addition to its negative role in the control of endocrine and exocrine secretions, somatostatin and analogs also exert inhibitory effects on the proliferation and survival of normal and tumor cells. Over the past 15 years, studies have begun to reveal some of the molecular mechanisms underlying the antitumor activity of somatostatin. This review covers the present knowledge in the antitumor effect of somatostatin and analogs and discusses the perspectives of novel clinical strategies based on somatostatin receptor sst2 gene transfer therapy.Since its discovery three decades ago as an inhibitor of GH release from the pituitary gland, somatostatin has attracted much attention because of its functional role in the regulation of a wide variety of physiological functions in the brain, pituitary, pancreas, gastrointestinal tract, adrenals, thyroid, kidney and immune system. In addition to its negative role in the control of endocrine and exocrine secretions, somatostatin and analogs also exert inhibitory effects on the proliferation and survival of normal and tumor cells. Over the past 15 years, studies have begun to reveal some of the molecular mechanisms underlying the antitumor activity of somatostatin. This review covers the present knowledge in the antitumor effect of somatostatin and analogs and discusses the perspectives of novel clinical strategies based on somatostatin receptor sst2 gene transfer therapy. |
| Author | Najib, Souad Azar, Rania Susini, Christiane Laklai, Hanane Pyronnet, Stéphane Bousquet, Corinne |
| Author_xml | – sequence: 1 givenname: Stéphane surname: Pyronnet fullname: Pyronnet, Stéphane – sequence: 2 givenname: Corinne surname: Bousquet fullname: Bousquet, Corinne – sequence: 3 givenname: Souad surname: Najib fullname: Najib, Souad – sequence: 4 givenname: Rania surname: Azar fullname: Azar, Rania – sequence: 5 givenname: Hanane surname: Laklai fullname: Laklai, Hanane – sequence: 6 givenname: Christiane surname: Susini fullname: Susini, Christiane email: susinich@toulouse.inserm.fr |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18359151$$D View this record in MEDLINE/PubMed https://hal.science/hal-00531996$$DView record in HAL |
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| Copyright | 2008 Elsevier Ireland Ltd Distributed under a Creative Commons Attribution 4.0 International License |
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| Keywords | Analogs Signaling Tumor Somatostatin Proliferation Receptor Life Sciences |
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| Title | Antitumor effects of somatostatin |
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