Causality Investigation between Gut Microbiota, Derived Metabolites, and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study

• Published in: Nutrients Vol. 15; no. 21; p. 4544
• Main Authors: Yan, Weiheng, Jiang, Miaomiao, Hu, Wen, Zhan, Xiaojun, Liu, Yifan, Zhou, Jiayi, Ji, Jie, Wang, Shan, Tai, Jun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 26.10.2023
• Subjects: Amino acids; Analysis; androsterone; Confounding (Statistics); digestive system; Fatty acids; Genomes; Gut microbiota; Human subjects; Hypertension; Hypoxia; intestinal microorganisms; leucine; Metabolism; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Oxidative stress; Probiotics; risk; Risk factors; Sleep apnea; Sleep apnea syndromes; Sulfates; Type 2 diabetes; variance; China

Various studies have highlighted the important associations between obstructive sleep apnea (OSA) and gut microbiota and related metabolites. Nevertheless, the establishment of causal relationships between these associations remains to be determined. Multiple mendelian randomization (MR) analyses we...