Infliximab-Related Infusion Reactions: Systematic Review

• Published in: Journal of Crohn's and colitis Vol. 9; no. 9; pp. 806 - 815
• Main Authors: Lichtenstein, Lev, Ron, Yulia, Kivity, Shmuel, Ben-Horin, Shomron, Israeli, Eran, Fraser, Gerald M., Dotan, Iris, Chowers, Yehuda, Confino-Cohen, Ronit, Weiss, Batia
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 01.09.2015
• Subjects: Anti-Inflammatory Agents - adverse effects; Anti-Inflammatory Agents - therapeutic use; Drug Hypersensitivity - etiology; Drug Hypersensitivity - prevention & control; Drug Hypersensitivity - therapy; Humans; Inflammatory Bowel Diseases - drug therapy; Infliximab - adverse effects; Infliximab - therapeutic use; Infusions, Intravenous; Review; infusion reactions; Infliximab; drug allergy; adverse drug reaction; drug toxicity; ulcerative colitis; drug hypersensitivity; inflammatory bowel disease; Crohn’s disease

Objective: Administration of infliximab is associated with a well-recognised risk of infusion reactions. Lack of a mechanism-based rationale for their prevention, and absence of adequate and well-controlled studies, has led to the use of diverse empirical administration protocols. The aim of this st...