Detection of rhinovirus RNA in lower airway cells during experimentally induced infection

• Published in: American journal of respiratory and critical care medicine Vol. 155; no. 3; p. 1159
• Main Authors: Gern, J E, Galagan, D M, Jarjour, N N, Dick, E C, Busse, W W
• Format: Journal Article
• Language: English
• Published: United States 01.03.1997
• Subjects: Adolescent; Adult; Bronchoalveolar Lavage Fluid - virology; Common Cold - virology; Humans; Middle Aged; Nasal Lavage Fluid - virology; Polymerase Chain Reaction; Respiratory Tract Diseases - virology; Rhinovirus - genetics; RNA, Viral - isolation & purification; Transcription, Genetic

Rhinovirus (RV) infections are presumed to be localized to the upper airway, yet can cause severe lower airway symptoms in children and adults with asthma. To test the hypothesis that rhinovirus infection of the upper airway may be associated with the presence of virus in lower airway cells, we used...