Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models - Rhode, Peter R; Egan, Jack O; Xu, Wenxin; Hong, Hao; Webb, Gabriela M; Chen, Xiaoyue; Liu, Bai; Zhu, Xiaoyun; Wen, Jinghai; You, Lijing; Kong, Lin; Edwards, Ana C; et al. (Cancer immunology research, 2016)
Keywords: Adjuvants, Immunologic - pharmacokinetics; Adjuvants, Immunologic - therapeutic use; Adjuvants, Immunologic - toxicity; Animals; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - therapeutic use; Antineoplastic Agents - toxicity; Cell Line, Tumor; Cell Proliferation; Cytokines - metabolism; Female; Humans; Immunotherapy; Interleukin-15 - pharmacokinetics; Interleukin-15 - therapeutic use; Interleukin-15 - toxicity; Killer Cells, Natural - drug effects; Killer Cells, Natural - physiology; Macaca fascicularis; Melanoma, Experimental - drug therapy; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Proteins - pharmacokinetics; Proteins - therapeutic use; Proteins - toxicity; Tissue Distribution; Tumor Burden - drug effects; Xenograft Model Antitumor Assays