Research progress of phosphatidylinositol 4-kinase and its inhibitors in inflammatory diseases

• Published in: European journal of pharmacology Vol. 907; p. 174300
• Main Authors: Li, Yan-ping, Mikrani, Reyaj, Hu, Yi-fan, Faran Ashraf Baig, Mirza Muhammad, Abbas, Muhammad, Akhtar, Fahad, Xu, Ming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.09.2021
• Subjects: 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors; 1-Phosphatidylinositol 4-Kinase - metabolism; Animals; Cancer; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Humans; Inflammation; Inflammation - drug therapy; Neoplasms - drug therapy; Phosphatidylinositol 4-kinase; PI4K inhibitors; Virus replication; Virus replication; Inflammation; Phosphatidylinositol 4-kinase; PI4K inhibitors; Cancer

Phosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in the phosphorylation of PtdIns at 4-OH sites, to generate phosphatidylinositol 4-phosphate (PI4P). Studies on biological...