Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways

• Published in: International immunopharmacology Vol. 38; pp. 349 - 356
• Main Authors: Guo, Chao, Yang, Lei, Luo, Jun, Zhang, Chao, Xia, Yuanzheng, Ma, Ting, Kong, Lingyi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Flavanones - pharmacology; Heme Oxygenase-1 - metabolism; Inflammation; Inflammation - drug therapy; Janus Kinases - metabolism; Lipopolysaccharides - immunology; LPS; Macrophages - drug effects; Macrophages - immunology; Membrane Proteins - metabolism; Mice; NF-E2-Related Factor 2 - metabolism; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; RAW 264.7 Cells; RAW264.7; Sophora - immunology; Sophoraflavanone G; STAT Transcription Factors - metabolism; NO; PGE2; COX-2; HO-1; Inflammation; IL-1β; LPS; IL-6; PIAS; NF-κB; STAT; SG; TNF-α; PI3K; Sophoraflavanone G; JAK; Nrf2; RAW264.7; Keap1; iNOS

Sophoraflavanone G (SG), a prenylated flavonoid from Sophora alopecuroides, has been reported to have many pharmacological activities including anti-inflammation. However, the molecular mechanisms of its anti-inflammatory activity remain largely unclear. In this study we investigated the effects and...