Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature

• Published in: Blood Vol. 105; no. 11; pp. 4337 - 4344
• Main Authors: May, Chad, Doody, Jacqueline F., Abdullah, Rashed, Balderes, Paul, Xu, Xiaohong, Chen, Chien Peter, Zhu, Zhenping, Shapiro, Lawrence, Kussie, Paul, Hicklin, Daniel J., Liao, Fang, Bohlen, Peter
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.06.2005; The Americain Society of Hematology
• Subjects: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal - pharmacology; Antigens, CD; Antigens, Neoplasm - immunology; Biological and medical sciences; Cadherins - immunology; Capillary Permeability - drug effects; Cell Line; Cell Proliferation - drug effects; Endothelium, Vascular; Epitope Mapping; Epitopes; Host-tumor relations. Immunology. Biological markers; Intercellular Junctions - drug effects; Medical sciences; Mice; Neoplasms - blood supply; Neoplasms - drug therapy; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - prevention & control; Tryptophan; Tumors; Human; Angiogenesis; Endothelial cell; Antigenic determinant; Cell junction; Tumor; Monoclonal antibody; Neovascularization; Malignant tumor; Cadherin; Adhesion

VE-cadherin is an adhesion molecule localized at the adherens junctions of endothelial cells. It is crucial for the proper assembly of vascular structures during angiogenesis and maintaining vascular integrity. We have studied 3 monoclonal antibodies (mAbs) against murine VE-cadherin that inhibit an...