Is Statin Use Associated With Tendon Rupture? A Population-Based Retrospective Cohort Analysis
Previous case reports and small studies have suggested that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (HMG-CoA-Is) may increase the risk of tendon rupture. We conducted a population-based retrospective cohort evaluation to better assess this relationship. From approximately 800,000 enrolle...
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Published in | American journal of therapeutics Vol. 22; no. 5; p. 377 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
01.09.2015
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Abstract | Previous case reports and small studies have suggested that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (HMG-CoA-Is) may increase the risk of tendon rupture. We conducted a population-based retrospective cohort evaluation to better assess this relationship. From approximately 800,000 enrollees of a private insurance database, those who were aged ≤64 years with at least 1 year of continuous enrollment were selected. Exposure was defined as initiation of HMG-CoA-I after the beginning of the study period. Each exposed person was matched with 2 controls of similar age and gender. Baseline characteristics, including known risk factors for tendon rupture, were compared between exposed and control cohorts with fidelity to the study's matched design. After adjusting for differences in follow-up and baseline characteristics, incidence rate ratios for tendon rupture was assessed in HMG-CoA-I users and nonusers. A total of 34,749 exposed patients were matched with 69,498 controls. There was no difference in the occurrence of tendon ruptures in HMG-CoA-I users versus nonusers. The results remained unchanged after adjustment for age and gender. In conclusion, this population-based retrospective cohort evaluation suggests that use of HMG-CoA-Is as a group are not associated with tendon rupture. |
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AbstractList | Previous case reports and small studies have suggested that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (HMG-CoA-Is) may increase the risk of tendon rupture. We conducted a population-based retrospective cohort evaluation to better assess this relationship. From approximately 800,000 enrollees of a private insurance database, those who were aged ≤64 years with at least 1 year of continuous enrollment were selected. Exposure was defined as initiation of HMG-CoA-I after the beginning of the study period. Each exposed person was matched with 2 controls of similar age and gender. Baseline characteristics, including known risk factors for tendon rupture, were compared between exposed and control cohorts with fidelity to the study's matched design. After adjusting for differences in follow-up and baseline characteristics, incidence rate ratios for tendon rupture was assessed in HMG-CoA-I users and nonusers. A total of 34,749 exposed patients were matched with 69,498 controls. There was no difference in the occurrence of tendon ruptures in HMG-CoA-I users versus nonusers. The results remained unchanged after adjustment for age and gender. In conclusion, this population-based retrospective cohort evaluation suggests that use of HMG-CoA-Is as a group are not associated with tendon rupture. |
Author | Tang, Xiaoqin Beri, Abhimanyu Gardiner, Joseph C Contractor, Tahmeed Dwamena, Francesca C |
Author_xml | – sequence: 1 givenname: Tahmeed surname: Contractor fullname: Contractor, Tahmeed organization: 1Division of Cardiology, Lehigh Valley Health Network, Allentown, PA; 2Department of Clinical Cardiac Electrophysiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA; 3Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI; 4Center for Health Research, Geisinger Health System, Danville, PA; and 5Department of Medicine, Michigan State University, East Lansing, MI – sequence: 2 givenname: Abhimanyu surname: Beri fullname: Beri, Abhimanyu – sequence: 3 givenname: Joseph C surname: Gardiner fullname: Gardiner, Joseph C – sequence: 4 givenname: Xiaoqin surname: Tang fullname: Tang, Xiaoqin – sequence: 5 givenname: Francesca C surname: Dwamena fullname: Dwamena, Francesca C |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24451300$$D View this record in MEDLINE/PubMed |
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Snippet | Previous case reports and small studies have suggested that 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (HMG-CoA-Is) may increase the risk of tendon... |
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SubjectTerms | Adult Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Insurance Claim Review Male Middle Aged Retrospective Studies Risk Factors Rupture Tendon Injuries - epidemiology |
Title | Is Statin Use Associated With Tendon Rupture? A Population-Based Retrospective Cohort Analysis |
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