Adherence Tradeoff to Multiple Preventive Therapies and All-Cause Mortality After Acute Myocardial Infarction

• Published in: Journal of the American College of Cardiology Vol. 70; no. 13; pp. 1543 - 1554
• Main Authors: Korhonen, Maarit J., Robinson, Jennifer G., Annis, Izabela E., Hickson, Ryan P., Bell, J. Simon, Hartikainen, Juha, Fang, Gang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.09.2017; Elsevier Limited
• Subjects: Adhesion; Adrenergic beta-Antagonists - therapeutic use; Age Factors; Aged; Aged, 80 and over; Angina pectoris; Angiotensin II; Angiotensin II Type 1 Receptor Blockers - therapeutic use; Angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Beta blockers; Cardiology; Chronic illnesses; Clinical trials; Confidence intervals; Coronary vessels; Diabetes; Disease prevention; Drug Therapy, Combination; Enzymes; Female; Government programs; Hazards; Health care; Health hazards; Health risk assessment; Heart attacks; Heart failure; Heart surgery; Hospitalization; Hospitals; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hypertension; Inhibitors; Male; Medicare; Medication Adherence; Meta-analysis; Mortality; Myocardial infarction; Myocardial Infarction - drug therapy; Myocardial Infarction - mortality; Myocardial Infarction - prevention & control; older adults; Older people; Patient compliance; Patients; Peptidyl-dipeptidase A; Proportional Hazards Models; secondary prevention; Statins; Statistical models; Tradeoffs; United States; CVD; ARB; secondary prevention; ACE; CI; myocardial infarction; older adults; HR; medication adherence; AMI; PDC

Angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARB), beta-blockers and statins are recommended after acute myocardial infarction (AMI). Patients may adhere to some, but not all, therapies. The authors investigated the effect of tradeoffs in adherence to ACE inhibito...