Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary

• Published in: Biochimica et biophysica acta. Molecular and cell biology of lipids Vol. 1868; no. 4; p. 159289
• Main Authors: Sun, Sheng-Xiang, Liu, Yi-Chan, Limbu, Samwel M., Li, Dong-Liang, Chen, Li-Qiao, Zhang, Mei-Ling, Yin, Zhan, Du, Zhen-Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2023
• Subjects: Animals; CRISPR/Cas 9; Docosahexaenoic acid; Docosahexaenoic Acids - pharmacology; Female; Lecithins; Liver; Ovary; Reproduction; Reproduction - physiology; Vitellogenins; Vitellogenins - pharmacology; Zebrafish; Zebrafish; Reproduction; Vitellogenins; Docosahexaenoic acid; CRISPR/Cas 9

Vitellogenins (Vtgs) are essential for female reproduction in oviparous animals, yet the exact roles and mechanisms remain unknown. In the present study, we knocked out vtg1, which is the most abundant Vtg in zebrafish, Danio rerio via the CRISPR/Cas 9 technology. We aimed to identify the roles of V...