Neuronostatin acts in brain to biphasically increase mean arterial pressure through sympatho-activation followed by vasopressin secretion: the role of melanocortin receptors

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 300; no. 5; pp. R1194 - R1199
• Main Authors: Yosten, Gina L C, Pate, Alicia T, Samson, Willis K
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2011
• Subjects: Adrenergic alpha-Antagonists - pharmacology; Animals; Blood Pressure - drug effects; Brain; Brain - drug effects; Brain - metabolism; Dose-Response Relationship, Drug; Hormone Antagonists - pharmacology; Hormones; Injections, Intraventricular; Male; Melanocyte-Stimulating Hormones - pharmacology; Nervous system; Peptide Fragments - administration & dosage; Peptides; Phentolamine - pharmacology; Rats; Receptors, Melanocortin - drug effects; Receptors, Melanocortin - metabolism; Receptors, Vasopressin - drug effects; Receptors, Vasopressin - metabolism; Rodents; Somatostatin - administration & dosage; Somatostatin - analogs & derivatives; Sympathetic Nervous System - drug effects; Time Factors; Vasopressins - metabolism

Neuronostatin is a recently described neuropeptide that is derived from the somatostatin preprohormone. We have shown previously that neuronostatin led to a biphasic, dose-related increase in mean arterial pressure when injected into the lateral cerebroventricle of adult, male rats. Because neuronos...