Catecholamine-Stimulated Cyclic GMP Accumulation in the Rat Pineal: Apparent Presynaptic Site of Action

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 73; no. 10; pp. 3398 - 3402
• Main Authors: O'Dea, Robert F., Zatz, Martin
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01.10.1976; National Acad Sciences
• Subjects: Acetylcholine - pharmacology; Adrenergic alpha-Antagonists - pharmacology; Agonists; Animals; Calcium; Calcium - pharmacology; Carbachol - pharmacology; Catecholamines; Cyclic AMP - metabolism; Cyclic GMP - metabolism; Cyclic nucleotides; Denervation; Dose-Response Relationship, Drug; Isoproterenol - pharmacology; Kinetics; Male; Melatonin - pharmacology; Nerves; Norepinephrine - pharmacology; Ouabain - pharmacology; Physiological regulation; Pineal gland; Pineal Gland - metabolism; Potassium; Potassium - pharmacology; Propranolol - pharmacology; Rats; Receptors; Receptors, Adrenergic - metabolism; Receptors, Adrenergic, alpha - metabolism; Sotalol - pharmacology; Stereoisomerism; Synaptic Membranes - metabolism

Guanosine 3′:5′-cyclic monophosphate (cGMP) increased 7-fold in rat pineal glands incubated in the presence of l-norepinephrine. This response consisted of two components-one was stereospecific and inhibited by α -adrenergic antagonists while the other was not stereospecific and not readily inhibite...